Gastrointestinal stromal tumors in Koreans: it's incidence and the clinical, pathologic and immunohistochemical findings

Seven hundred forty seven cases of gastrointestinal stromal tumors (GISTs) in Koreans who were diagnosed between 2001 and 2002 were analyzed to evaluate their occurrence and their clinical, pathologic and immunohistochemical findings. The most frequent location of tumor was in the stomach (63%), fol...

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Published in:Journal of Korean medical science 2005, 20(6), , pp.977-984
Main Authors: Kim, Kyoung-Mee, Kang, Dong Wook, Moon, Woo Sung, Park, Jae Bok, Park, Cheol Keun, Sohn, Jin Hee, Jeong, Jin Sook, Cho, Mee-Yon, Jin, So-Young, Choi, Jong Sang, Kang, Dae Young
Format: Article
Language:English
Subjects:
Actins - metabolism
Adolescent
Adult
Aged
Aged, 80 and over
Antigens, CD34 - metabolism
Child
Female
Gastrointestinal Stromal Tumors - epidemiology
Gastrointestinal Stromal Tumors - metabolism
Gastrointestinal Stromal Tumors - pathology
Humans
Immunohistochemistry
Korea - epidemiology
Male
Middle Aged
Original
Prognosis
Proto-Oncogene Proteins c-kit - metabolism
S100 Proteins - metabolism
의학일반
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Summary:Seven hundred forty seven cases of gastrointestinal stromal tumors (GISTs) in Koreans who were diagnosed between 2001 and 2002 were analyzed to evaluate their occurrence and their clinical, pathologic and immunohistochemical findings. The most frequent location of tumor was in the stomach (63%), followed by the small intestine (30%), the colorectum (5%), and the esophagus (2%). c-kit expression was found in 93.6% of the cases, while CD34, SMA and S-100 protein was positive in 80.1%, 28.2%, and 20.2%, respectively. c-kit positivity was high in the stomach (94.2%) and small intestine (94.6%), while it was relatively low in the colorectum (85.0%), and esophagus (81.2%). The positivity for CD34 was correlated with the higher risk of GISTs (p = 0.04). Follow up of the patients showed that 58 primary GISTs patients died and 20 of these patients were recurrent or metastatic at the time of diagnosis. The pathologic diagnosis to predict the risk of aggressive behavior of GISTs was correlated with the numbers of tumor, clinical stage, epithelioid histologic type, cellularity, cellular atypia, necrosis, and mucosal invasion (p = 0.00). GISTs with a poor prognosis were closely related to the clinical stage at presentation, the locations of the tumor, and the ages of the patients.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2005.20.6.977