Ginsenosides: the need to move forward from bench to clinical trials

Panax ginseng, known as Koran ginseng, one of the most commonly used traditional plants, has been demonstrated to show a wide range of pharmacological applications. Ginsenosides are the major active ingredients found in ginseng and are responsible for the biological and pharmacological activities, s...

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Bibliographic Details
Published in:Journal of ginseng research 2019, 43(3), , pp.361-367
Main Authors: Yu, Seung Eun, Mwesige, Benjamin, Yi, Young-Su, Yoo, Byong Chul
Format: Article
Language:English
Subjects:
Clinical trial
Ginseng
Ginsenoside
Protopanaxadiol
Protopanaxatriol
Short Review
기타의약학
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Summary:Panax ginseng, known as Koran ginseng, one of the most commonly used traditional plants, has been demonstrated to show a wide range of pharmacological applications. Ginsenosides are the major active ingredients found in ginseng and are responsible for the biological and pharmacological activities, such as antioxidation, antiinflammation, vasorelaxation, and anticancer actions. Existing studies have mostly focused on identifying and purifying single ginsenosides and investigating pharmacological activities and molecular mechanisms in cells and animal models. However, ginsenoside studies based on clinical trials have been very limited. Therefore, this review aimed to discuss the currently available clinical trials on ginsenosides and provide insights and future directions for developing ginsenosides as efficacious and safe drugs for human disease.
ISSN:1226-8453
2093-4947
DOI:10.1016/j.jgr.2018.09.001