The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates

Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. Many risk factors can contribute to the development of NEC. The epidermal growth factor (EGF) plays a major role in intestinal barrier function, increases intestinal enzyme activity, and improves nutrient transp...

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Bibliographic Details
Published in:Clinical and experimental pediatrics 2019, 62(8), , pp.307-311
Main Authors: Ahmed, Heba Mostafa, Kamel, Nsreen Mostafa
Format: Article
Language:English
Subjects:
Abdomen
Antibiotics
Biomarkers
Blood
Epidermal growth factor
Laboratories
Mortality
Necrotizing enterocolitis
Neonates
Original
Proteins
Sepsis
소아과학
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Summary:Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. Many risk factors can contribute to the development of NEC. The epidermal growth factor (EGF) plays a major role in intestinal barrier function, increases intestinal enzyme activity, and improves nutrient transport. The aim of this study was to assess the role of epidermal growth factor in the development of NEC in preterm neonates. In this study, 130 preterm neonates were included and divided into 3 groups, as follows: group 1, 40 preterm neonates with NEC; group 2, 50 preterm neonates with sepsis; and group 3, 40 healthy preterm neonates as controls. The NEC group was then subdivided into medical and surgical NEC subgroups. The serum EGF level was measured using enzyme-linked immunosorbent assay. Serum EGF levels (pg/dL) were significantly lower in the NEC group (median [interquartile range, IQR], 9.6 [2-14]) than in the sepsis (10.1 [8-14]) and control groups (11.2 [8-14], P
ISSN:1738-1061
2092-7258
2713-4148
DOI:10.3345/kjp.2018.07108