β-Glucan hybridized poly(ethylene glycol) microgels for macrophage-targeted protein delivery

[Display omitted] •PEG/schizophyllan microgels formed via thiol-ene click reaction in aqueous two-phase emulsion.•Tunable microgel property for macrophage-targeted delivery.•Excellent internalization of microgel in macrophage through receptor-mediated phagocytosis. Macrophages are crucial target cel...

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Bibliographic Details
Published in:Journal of industrial and engineering chemistry (Seoul, Korea) 2019, 75(0), , pp.69-76
Main Authors: Tae, Hyunhyuk, Lee, Sora, Ki, Chang Seok
Format: Article
Language:English
Subjects:
Beta-glucan
Macrophage
Microgel
Poly(ethylene glycol)
화학공학
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Summary:[Display omitted] •PEG/schizophyllan microgels formed via thiol-ene click reaction in aqueous two-phase emulsion.•Tunable microgel property for macrophage-targeted delivery.•Excellent internalization of microgel in macrophage through receptor-mediated phagocytosis. Macrophages are crucial target cells for drug delivery due to their important roles in immune responses. An immunomodulating polysaccharide, β-glucan, was incorporated into poly(ethylene glycol) microgels via thiol-ene photo-crosslinking. Hybrid microgels of uniform size were obtained. The incorporation of β-glucan was confirmed by fluorescence observations and changes in surface charges. Cellular uptake test results demonstrated that the hybrid microgels were selectively internalized by murine macrophages. Such selective internalization was induced by β-glucan-mediated phagocytosis. The model drug release assay showed that bovine serum albumin loaded into the microgels was gradually released under both neutral and acidic conditions.
ISSN:1226-086X
1876-794X
DOI:10.1016/j.jiec.2019.02.014