Human Induced Pluripotent Stem Cells : Clinical Significance and Applications in Neurologic Diseases

The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of essential platforms for targeted drug development. iPSCs retain the genome of the donor, may reg...

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Bibliographic Details
Published in:Journal of Korean Neurosurgical Society 2019, 62(5), , pp.493-501
Main Authors: Chang, Eun-Ah, Jin, Sung-Won, Nam, Myung-Hyun, Kim, Sang-Dae
Format: Article
Language:English
Subjects:
Review
신경외과학
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Summary:The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of essential platforms for targeted drug development. iPSCs retain the genome of the donor, may regenerate indefinitely, and undergo differentiation into virtually any cell type of interest using a range of published protocols. There has been enormous interest among researchers regarding the application of iPSC technology to regenerative medicine and human disease modeling, in particular, modeling of neurologic diseases using patient-specific iPSCs. For instance, Parkinson's disease, Alzheimer's disease, and spinal cord injuries may be treated with iPSC therapy or replacement tissues obtained from iPSCs. In this review, we discuss the work so far on generation and characterization of iPSCs and focus on recent advances in the use of human iPSCs in clinical setting.
ISSN:2005-3711
1598-7876
DOI:10.3340/jkns.2018.0222