PKconverter: R package to convert the pharmacokinetic parameters

Population pharmacokinetic analysis and modeling procedures typically require estimates of both population and individual pharmacokinetic parameters. However, only some of these parameters are contained in models and only parameters in the model can be estimated. In this paper, we introduce a new R...

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Bibliographic Details
Published in:Translational and clinical pharmacology 2019, 27(2), , pp.73-79
Main Authors: Cho, Hyeseon, Lee, Eun-Kyung
Format: Article
Language:English
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Original
의약학
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Summary:Population pharmacokinetic analysis and modeling procedures typically require estimates of both population and individual pharmacokinetic parameters. However, only some of these parameters are contained in models and only parameters in the model can be estimated. In this paper, we introduce a new R package, PKconverter, to calculate pharmacokinetic parameters using the relationships among them. After fitting the model, other parameters can be calculated from the functional relationship among the parameters. PKconverter provides the functions to calculate whole parameters along with a Shiny application for converting the parameters. With this package, it is also possible to calculate the standard errors of the other parameters that are not in the model and estimate individual parameters simultaneously.
ISSN:2289-0882
2383-5427
DOI:10.12793/tcp.2019.27.2.73