Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis

This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis. The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were per...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research and treatment 2019, 51(4), , pp.1653-1665
Main Authors: Li, Nan, Piao, Junjie, Wang, Xinyue, Kim, Ki-Yeol, Bae, Jung Yoon, Ren, Xiangshan, Lin, Zhenhua
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor - metabolism
Cell Line, Tumor
Cell Proliferation
Female
Gene Expression Regulation, Neoplastic
HeLa Cells
Humans
Mice
Neoplasm Transplantation
Original
Peptide Initiation Factors - metabolism
Prognosis
RNA-Binding Proteins - metabolism
Survival Analysis
Up-Regulation
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - pathology
의약학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis. The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression. Paip1 was found to be up-regulated in CC, which was linked with shorter survival. Knockdown of Paip1 inhibited cell growth, induced apoptosis and cell cycle arrest in CC cells, whereas its overexpression reversed these effects. The in vivo tumor model confirmed the pro-tumor role of Paip1 in CC growth. Altogether, the investigation demonstrated the clinical significance of Paip1 expression, which prompted that the up-regulated of Paip1 can presumably be a potential prognostic and progression marker for CC.
ISSN:1598-2998
2005-9256
DOI:10.4143/crt.2018.544