Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis

This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis. The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were per...

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Published in:Cancer research and treatment 2019, 51(4), , pp.1653-1665
Main Authors: Li, Nan, Piao, Junjie, Wang, Xinyue, Kim, Ki-Yeol, Bae, Jung Yoon, Ren, Xiangshan, Lin, Zhenhua
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor - metabolism
Cell Line, Tumor
Cell Proliferation
Female
Gene Expression Regulation, Neoplastic
HeLa Cells
Humans
Mice
Neoplasm Transplantation
Original
Peptide Initiation Factors - metabolism
Prognosis
RNA-Binding Proteins - metabolism
Survival Analysis
Up-Regulation
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - pathology
의약학
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cited_by cdi_FETCH-LOGICAL-c484t-dff982947af073e112c90e8721c63f08ca5fde25900ba0504088f78997fe9f5d3
cites cdi_FETCH-LOGICAL-c484t-dff982947af073e112c90e8721c63f08ca5fde25900ba0504088f78997fe9f5d3
container_end_page 1665
container_issue 4
container_start_page 1653
container_title Cancer research and treatment
container_volume 51
creator Li, Nan
Piao, Junjie
Wang, Xinyue
Kim, Ki-Yeol
Bae, Jung Yoon
Ren, Xiangshan
Lin, Zhenhua
description This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis. The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression. Paip1 was found to be up-regulated in CC, which was linked with shorter survival. Knockdown of Paip1 inhibited cell growth, induced apoptosis and cell cycle arrest in CC cells, whereas its overexpression reversed these effects. The in vivo tumor model confirmed the pro-tumor role of Paip1 in CC growth. Altogether, the investigation demonstrated the clinical significance of Paip1 expression, which prompted that the up-regulated of Paip1 can presumably be a potential prognostic and progression marker for CC.
doi_str_mv 10.4143/crt.2018.544
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source PubMed Central (Open access)
subjects Animals
Biomarkers, Tumor - metabolism
Cell Line, Tumor
Cell Proliferation
Female
Gene Expression Regulation, Neoplastic
HeLa Cells
Humans
Mice
Neoplasm Transplantation
Original
Peptide Initiation Factors - metabolism
Prognosis
RNA-Binding Proteins - metabolism
Survival Analysis
Up-Regulation
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - pathology
의약학
title Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis
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