Attenuation of hyperoxic acute lung injury by Lycium barbarum polysaccharide via inhibiting NLRP3 inflammasome

Lycium barbarum polysaccharide (LBP), an active component from Goji berry which is a traditional Chinese medicine, has anti-inflammatory and antioxidant features. The aim of our study was to investigate whether LBP has any role in hyperoxia-induced acute lung injury (ALI). Using a murine model of hy...

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Bibliographic Details
Published in:Archives of pharmacal research 2019, 42(10), , pp.902-908
Main Authors: Hong, Cheng-Ying, Zhang, Hua-Dong, Liu, Xue-Yan, Xu, Yong
Format: Article
Language:English
Subjects:
Acute Lung Injury - drug therapy
Acute Lung Injury - metabolism
Acute Lung Injury - pathology
Animals
Drugs, Chinese Herbal - pharmacology
Hyperoxia - drug therapy
Hyperoxia - metabolism
Hyperoxia - pathology
Inflammasomes - drug effects
Inflammasomes - metabolism
Male
Medicine
Mice
Mice, Inbred C57BL
NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors
NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
Pharmacology/Toxicology
Pharmacy
Research Article
약학
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Summary:Lycium barbarum polysaccharide (LBP), an active component from Goji berry which is a traditional Chinese medicine, has anti-inflammatory and antioxidant features. The aim of our study was to investigate whether LBP has any role in hyperoxia-induced acute lung injury (ALI). Using a murine model of hyperoxia-induced ALI, we investigate the effect of LBP on pulmonary pathological changes as well as Sirtuin 1 (SIRT1) and the nucleotide binding domain and leucine-rich repeat pyrin domain containing 3 (NLRP3) inflammasome. Exposure to 100% oxygen for 72 h in male C57BL/6 mice resulted in increased protein levels of tumor necrosis factor-α and interleukin-1β in lung tissues, and aggravated lung histological alterations. These hyperoxia-induced changes and mortality were improved by LBP. LBP markedly suppressed the activation of NLRP3 inflammasome both in vivo and in vitro. Moreover, LBP upregulated SIRT1 expression compared with vehicle-treated group. Importantly, knockdown of SIRT1 reversed the inhibitory effect of LBP on NLRP3 inflammasome activation in vitro. LBP meliorated hyperoxia-induced ALI in mice by SIRT1-dependent inhibition of NLRP3 inflammasome activation.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-019-01175-4