Transfer RNA-Derived Small Non-Coding RNA: Dual Regulator of Protein Synthesis

Transfer RNA-derived small RNAs (tsRNAs) play a role in various cellular processes. Accumulating evidence has revealed that tsRNAs are deeply implicated in human diseases, such as various cancers and neurological disorders, suggesting that tsRNAs should be investigated to develop novel therapeutic i...

Full description

Saved in:
Bibliographic Details
Published in:Molecules and cells 2019, 42(10), , pp.687-692
Main Author: Kim, Hak Kyun
Format: Article
Language:English
Subjects:
Amino Acyl-tRNA Synthetases - metabolism
Animals
Humans
Minireview
Protein Biosynthesis
Ribosomes - metabolism
RNA, Small Untranslated - metabolism
RNA, Transfer - metabolism
Stress, Physiological
생물학
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Transfer RNA-derived small RNAs (tsRNAs) play a role in various cellular processes. Accumulating evidence has revealed that tsRNAs are deeply implicated in human diseases, such as various cancers and neurological disorders, suggesting that tsRNAs should be investigated to develop novel therapeutic intervention. tsRNAs provide more complexity to the physiological role of transfer RNAs by repressing or activating protein synthesis with distinct mechanisms. Here, we highlight the detailed mechanism of tsRNA-mediated dual regulation in protein synthesis and discuss the necessity of novel sequencing technology to learn more about tsRNAs.
ISSN:1016-8478
0219-1032
DOI:10.14348/molcells.2019.0214