Single-nozzle Core-shell Electrospun Nanofibers of PVP/Dextran as Drug Delivery System

Ciprofloxacin-loaded poly(vinylpyrrolidinone) (PVP) and dextran sulfate (Dex) (PVP/Dex) nanofibers were prepared using the emulsion electrospinning method. The physical and morphological characteristics of the prepared nanofibers were evaluated by conducting a Fourier transform infrared spectroscopy...

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Bibliographic Details
Published in:Fibers and polymers 2019, 20(10), , pp.2078-2089
Main Authors: Moydeen, A. Meera, Padusha, M. Syed Ali, Thamer, Badr M., Ahamed N., Anis, Al-Enizi, Abdullah M., El-Hamshary, Hany, El-Newehy, Mohamed H.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Core-shell structure
Drug delivery systems
Electron microscopy
Fourier transforms
Infrared analysis
Infrared spectroscopy
Klebsiella
Laser microscopy
Microscopy
Nanofibers
Nozzles
Polymer Sciences
Polymers
Polyvinylpyrrolidinone
Pseudomonas aeruginosa
Regression analysis
Salmonella
Spectrum analysis
Staphylococcus infections
Sustained release
Thermogravimetric analysis
섬유공학
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Summary:Ciprofloxacin-loaded poly(vinylpyrrolidinone) (PVP) and dextran sulfate (Dex) (PVP/Dex) nanofibers were prepared using the emulsion electrospinning method. The physical and morphological characteristics of the prepared nanofibers were evaluated by conducting a Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). The polymer-polymer and polymer-drug interactions were determined using differential scanning calorimetry (DSC). Moreover, the formation of the core-shell structure was confirmed by transmission electron microscopy (TEM) and confocal laser microscopy. The sustained release behavior was evaluated using ultraviolet-visible (UV-vis) spectroscopy, and its kinetic mechanism was investigated using Korsmeyer-Peppas, Peppas-Sahlin, and Weibull models by a non-linear regression equation. The antibacterial properties were evaluated using the disc diffusion method with respect to several wound gram-positive (Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Staphylococcus aureus , and Klebsiella pneumoniae ) and gram-negative bacteria ( Pseudomonas aeruginosa, Salmonella typhimurium , and Proteus vulgaris ). In general, the release behavior of Ciprofloxacin from PVP/Dex is controlled by diffusion in the delivery system.
ISSN:1229-9197
1875-0052
DOI:10.1007/s12221-019-9187-2