Single-nozzle Core-shell Electrospun Nanofibers of PVP/Dextran as Drug Delivery System

• Published in: Fibers and polymers 2019, 20(10), , pp.2078-2089
• Main Authors: Moydeen, A. Meera, Padusha, M. Syed Ali, Thamer, Badr M., Ahamed N., Anis, Al-Enizi, Abdullah M., El-Hamshary, Hany, El-Newehy, Mohamed H.
• Format: Article
• Language: English
• Subjects: Chemistry; Chemistry and Materials Science; Core-shell structure; Drug delivery systems; Electron microscopy; Fourier transforms; Infrared analysis; Infrared spectroscopy; Klebsiella; Laser microscopy; Microscopy; Nanofibers; Nozzles; Polymer Sciences; Polymers; Polyvinylpyrrolidinone; Pseudomonas aeruginosa; Regression analysis; Salmonella; Spectrum analysis; Staphylococcus infections; Sustained release; Thermogravimetric analysis; 섬유공학
• ISSN: 1229-9197; 1875-0052
• DOI: 10.1007/s12221-019-9187-2

Ciprofloxacin-loaded poly(vinylpyrrolidinone) (PVP) and dextran sulfate (Dex) (PVP/Dex) nanofibers were prepared using the emulsion electrospinning method. The physical and morphological characteristics of the prepared nanofibers were evaluated by conducting a Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). The polymer-polymer and polymer-drug interactions were determined using differential scanning calorimetry (DSC). Moreover, the formation of the core-shell structure was confirmed by transmission electron microscopy (TEM) and confocal laser microscopy. The sustained release behavior was evaluated using ultraviolet-visible (UV-vis) spectroscopy, and its kinetic mechanism was investigated using Korsmeyer-Peppas, Peppas-Sahlin, and Weibull models by a non-linear regression equation. The antibacterial properties were evaluated using the disc diffusion method with respect to several wound gram-positive (Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Staphylococcus aureus , and Klebsiella pneumoniae ) and gram-negative bacteria ( Pseudomonas aeruginosa, Salmonella typhimurium , and Proteus vulgaris ). In general, the release behavior of Ciprofloxacin from PVP/Dex is controlled by diffusion in the delivery system.