JL1 Antigen Expression on Bone Marrow Lymphoma Cells from Patients With Non-Hodgkin Lymphoma

• Published in: Annals of laboratory medicine 2020, 40(1), , pp.1-6
• Main Authors: Kim, Min Sun, Park, Chan Jeoung, Cho, Young Uk, Jang, Seongsoo, Seo, Eul Ju, Park, Chan Sik, Huh, Jooryung, Im, Ho Joon, Seo, Jong Jin, Yoon, Dok Hyun, Suh, Cheolwon
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antigens, Differentiation, T-Lymphocyte - metabolism; Bone Marrow Cells - cytology; Bone Marrow Cells - metabolism; Child; Child, Preschool; Female; Flow Cytometry; Humans; Killer Cells, Natural - cytology; Killer Cells, Natural - metabolism; Lymphoma, B-Cell - metabolism; Lymphoma, B-Cell - pathology; Male; Middle Aged; Original; T-Lymphocytes - cytology; T-Lymphocytes - metabolism; Young Adult; 병리학
• ISSN: 2234-3806; 2234-3814
• DOI: 10.3343/alm.2020.40.1.1

JL1, a CD43 epitope and mucin family cell surface glycoprotein, is expressed on leukemic cells. An anti-JL1 antibody combined with a toxic substance can have targeted therapeutic effects against JL1-positive leukemia; however, JL1 expression on bone marrow (BM) lymphoma cells has not been assessed using flow cytometry. We investigated JL1 expression on BM lymphoma cells from patients with non-Hodgkin lymphoma (NHL) to assess the potential of JL1 as a therapeutic target. Patients with BM involvement of mature B-cell (N=44) or T- and natural killer (NK)-cell (N=4) lymphomas were enrolled from May 2015 to September 2016. JL1 expression on BM lymphoma cells was investigated using flow cytometry. Clinical, pathological, and cytogenetic characteristics, and treatment responses were compared according to JL1 expression status. Of the patients with NHL and BM involvement, 37.5% (18/48) were JL1-positive. Among mature B-cell lymphomas, 100%, 38.9%, 33.3%, 100%, and 25.0% of Burkitt lymphomas, diffuse large B-cell leukemias, mantle cell leukemias, Waldenstrom macroglobulinemia, and other B-cell lymphomas, respectively, were JL1-positive. Three mature T- and NK-cell NHLs were JL1-positive. JL1 expression was associated with age ( =0.045), complete response ( =0.004), and BM involvement at follow-up ( =0.017), but not with sex, performance status, the B symptoms, packed marrow pattern, cytogenetic abnormalities, or survival. JL1 positivity was associated with superior complete response and less BM involvement in NHL following chemotherapy.