Increased Progastrin-Releasing Peptide Expression is Associated with Progression in Gastric Cancer Patients

The purpose of this study was to assess the diagnostic and prognostic value of serum progastrin-releasing peptide (ProGRP) in patients with gastric cancer (GC). A total of 150 patients with GC (89 males and 61 females) were recruited, including those with stage I (n=28), stage II (n=33), stage III (...

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Bibliographic Details
Published in:Yonsei medical journal 2020, 61(1), , pp.15-19
Main Authors: Li, Li, Yin, Xiaodong, Meng, Hai, Hu, Juanyu, Yu, Zhengqing, Xu, Jianyong
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens, Tumor-Associated, Carbohydrate - blood
Biomarkers, Tumor - blood
Carcinoembryonic Antigen - blood
Case-Control Studies
Disease Progression
Female
GPI-Linked Proteins - blood
Humans
Male
Middle Aged
Original
Peptide Fragments - blood
Peptide Fragments - metabolism
Prognosis
Recombinant Proteins - blood
Recombinant Proteins - metabolism
ROC Curve
Sensitivity and Specificity
Stomach Neoplasms - blood
Stomach Neoplasms - diagnosis
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
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Summary:The purpose of this study was to assess the diagnostic and prognostic value of serum progastrin-releasing peptide (ProGRP) in patients with gastric cancer (GC). A total of 150 patients with GC (89 males and 61 females) were recruited, including those with stage I (n=28), stage II (n=33), stage III (n=50), and stage IV (n=39) disease; 50 healthy controls and 66 patients with benign gastric diseases were also enrolled. Levels of serum ProGRP, carcinoembryonic antigen (CEA), and carbohydrate antigen 72-4 (CA72-4) were measured in all subjects. Serum ProGRP levels were significantly higher in GC patients than in controls (
ISSN:0513-5796
1976-2437
DOI:10.3349/ymj.2020.61.1.15