A Review of Electrical Impedance Characterization of Cells for Label-Free and Real-Time Assays

The aim of this review is to discuss label-free and real-time assays characterizing the electrical impedance of cells for biomedical and pharmacological applications. Electrical impedance measurements can be used to non-destructively monitor cellular behavior by analyzing the electrical cell-substra...

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Bibliographic Details
Published in:Biochip journal 2019, 13(4), , pp.295-305
Main Authors: Ngoc Le, Hien T., Kim, Junsub, Park, Jinsoo, Cho, Sungbo
Format: Article
Language:English
Subjects:
Apoptosis
Bioactive compounds
Biocompatibility
Biomedical Engineering and Bioengineering
Biotechnology
Cell adhesion & migration
Cell cycle
Cell growth
Cell migration
Cell signaling
Chemistry
Chronic illnesses
Cytology
Cytoplasm
Cytotoxicity
Dielectric properties
Electric currents
Electrical impedance
Electrical properties
Electrodes
Fibroblasts
High-throughput screening
Investigations
Labels
Nanoparticles
Pharmacology
Real time
Review Article
Smooth muscle
Stem cells
Stimulants
Substrates
Wound healing
생물공학
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Summary:The aim of this review is to discuss label-free and real-time assays characterizing the electrical impedance of cells for biomedical and pharmacological applications. Electrical impedance measurements can be used to non-destructively monitor cellular behavior by analyzing the electrical cell-substrate impedance, which is determined by cellular morphology and distribution on the sensing electrode. Cellular electrical impedance measurements can be used to analyze the effects of various therapeutic agents, nanoparticles, naturally derived bioactive compounds, chemotaxins, or other stimulants on cellular cytotoxicity, motility, migration, invasion, and proliferation. This method is becoming increasingly widespread, with applications ranging from basic studies of the cell cycle, cell signaling, chronic disease, and pathophysiological mechanisms to smart cell monitoring and high-throughput screening, which are required by the pharmacological industry.
ISSN:1976-0280
2092-7843
DOI:10.1007/s13206-019-3401-6