Characteristics of Faecal Microbiota in Korean Patients with Clostridioides difficile -associated Diarrhea

• Published in: Infection & chemotherapy 2019, 51(4), , pp.365-375
• Main Authors: Jeon, Yong Duk, Ann, Hea Won, Lee, Woon Ji, Kim, Jun Hyoung, Seong, Hye, Kim, Jung Ho, Ahn, Jin Young, Jeong, Su Jin, Ku, Nam Su, Yeom, Joon Sup, Yong, Dongeun, Lee, Kyungwon, Choi, Jun Yong
• Format: Article
• Language: English
• Subjects: Original; 내과학
• ISSN: 2093-2340; 2092-6448
• DOI: 10.3947/ic.2019.51.4.365

The intestinal microbiota plays an important role in the pathogenesis of -associated diarrhea, and regional and racial characteristics influence the microbiome composition and diversity. We investigated the intestinal microbiome characteristics of patients with colitis (CD+) compared to those of patients with colitis not due to (CD-), patients with vancomycin-resistant enterococci (VRE) colonization, and healthy controls, in Korea. We collected stool samples from 24, 18, 11 and 13 subjects within CD+, CD-, VRE and healthy control groups, respectively. The microbial communities were evaluated by 454-pyrosequencing of bacterial 16s rRNA. The species richness and microbial diversity were significantly lower in the CD+ group compared to those in healthy controls, but not compared to those in CD- and VRE groups. Phylum-level analysis showed that the proportion of Actinobacteria in the CD+ group was significantly lower than in the healthy control, but was unchanged compared to that in CD- and VRE groups. At the genus level, compared to the healthy group, the CD+ group showed significantly lower proportions of , , et al. Compared to the VRE group, the CD+ group showed a significantly higher proportion of . We could identify the intestinal microbiome characteristics of Koreans with colitis. It might help to develop microbiome based diagnostic and treatment modalities.