Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice

In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced...

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Bibliographic Details
Published in:Food science and biotechnology 2020, 29(2), , pp.275-281
Main Authors: Kim, Hwa-Jin, You, Mi-Kyoung, Wang, Ziyun, Lee, Young-Hyeon, Kim, Hyeon-A
Format: Article
Language:English
Subjects:
Adipose tissue
AMP-activated protein kinase
Body fat
Body weight
Chemistry
Chemistry and Materials Science
Diet
Dual energy X-ray absorptiometry
Food Science
Gene expression
High fat diet
Homeostasis
Hyperlipidemia
Insulin
Kinases
Nutrition
Obesity
Transcription activation
Transcription factors
식품과학
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Summary:In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced increases in body weight and adipose tissue weight. The patterns of the adipose tissue weights were parallel to the patterns of fat area, as measured in DXA procedure. In the adipose tissue, RPS suppressed the expression of adipogenic transcription factors and adipose marker genes. AMP-activated protein kinase activation was observed in the adipose tissue by RPS treatment. In addition, RPS improved high homeostasis model assessment of insulin resistance and hyperlipidemia in HFD fed mice. These findings suggest that RPS can be used as a potential therapeutic substance for reducing body fat and obesity related diseases.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-019-00710-9