Mangiferin ameliorates placental oxidative stress and activates PI3K/Akt/mTOR pathway in mouse model of preeclampsia

• Published in: Archives of pharmacal research 2020, 43(2), , pp.233-241
• Main Authors: Huang, Jing, Zheng, Lili, Wang, Fang, Su, Yuan, Kong, Hongfang, Xin, Hong
• Format: Article
• Language: English
• Subjects: Animals; Blood Pressure - drug effects; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Medicine; Mice; Mice, Inbred ICR; Molecular Structure; Oxidative Stress - drug effects; Pharmacology/Toxicology; Pharmacy; Phosphatidylinositol 3-Kinases - metabolism; Placenta - drug effects; Pre-Eclampsia - drug therapy; Pre-Eclampsia - metabolism; Pregnancy; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Proto-Oncogene Proteins c-akt - metabolism; Research Article; Structure-Activity Relationship; TOR Serine-Threonine Kinases - antagonists & inhibitors; TOR Serine-Threonine Kinases - metabolism; Xanthones - pharmacology; 약학
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/s12272-020-01220-7

Preeclampsia is an inflammatory disease which can induce oxidative stress in placenta. Oxidative stress in preeclampsia is regulated by the phosphatidylinositol-3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway. Mangiferin, an anti-oxidative molecule, is reported to ameliorate oxidative stress in the kidney and brain through activating the PI3K/Akt/mTOR pathway. We aimed to investigate the effects of mangiferin in a mouse model of preeclampsia, which was induced by phosphatidylserine/dioleoyl-phosphatidycholine (PS/PC) from day 5 to 17 of pregnancy. The female pregnant mice were divided into five groups according to drug treatment. Animals received mangiferin orally at doses of 10, 20, 40 mg/kg/day from day 0.5 to 17. In preeclampsia mouse model, elevated systolic blood pressure and proteinuria were ameliorated by mangiferin treatment. Mangiferin attenuated fms-like tyrosine kinase-1 and placental growth factor expression and oxidative stress in both blood and placenta of preeclampsia mice. The suppressed PI3K/Akt/mTOR pathway in placenta was activated by mangiferin treatment. This study demonstrates that mangiferin ameliorates placental oxidative stress and activates PI3K/Akt/mTOR pathway in a mouse model of preeclampsia.