Anti-inflammatory Effects of Sargachromanol I, Sargachromanol G, and Saringosterol from Hexane Fraction of Myagropsis myagroides

The anti-inflammatory activity of benzopyran derivatives extracted from the Myagropsis myagroides against lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophage cell line was examined. The three constituents of M. myagroides extracts were identified as the sargachromanol G, sargachromanol I, a...

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Published in:Biotechnology and bioprocess engineering 2020, 25(1), , pp.16-21
Main Authors: Kim, Koth-Bong-Woo-Ri, Jeong, So-Mi, Jeong, Da-Hyun, Kim, Min-Ji, Ahn, Dong-Hyun
Format: Article
Language:English
Subjects:
Autoclaving
Biotechnology
Botryococcus braunii
Cell disruption
Chemistry
Chemistry and Materials Science
Chloroform
Disruption
Esterification
Fatty acids
Flasks
Industrial and Production Engineering
Lipids
Lipopolysaccharides
Osmotic shock
Research Paper
Sulfuric acid
Transesterification
생물공학
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Summary:The anti-inflammatory activity of benzopyran derivatives extracted from the Myagropsis myagroides against lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophage cell line was examined. The three constituents of M. myagroides extracts were identified as the sargachromanol G, sargachromanol I, and saringosterol by 1 H and 13 C NMR. Sargachromanol G, sargachromanol I, and saringosterol at concentrations of 50 μg/mL showed inhibitory effects on LPS induced interleukin-6 production (by 84%, 90%, and 96%, respectively) and tumor necrosis factor (by 74%, 82%, and 98%, respectively). These results confirm the potential anti-inflammatory effects of sarga-chromanol G, sargachromanol I, and saringosterol.
ISSN:1226-8372
1976-3816
DOI:10.1007/s12257-019-0277-1