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Imatinib mesylate-induced interstitial lung disease in a patient with prior history of Mycobacterium tuberculosis infection

In conclusion, we presented a rare case of ILD associated with IM therapy in a patient with GIST. It is important to have a high index of suspicion for this rare pulmonary toxicity when patients, in particular with preexisting lung disease, have unexplained lung infiltrates regardless of pulmonary s...

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Published in:The Korean journal of internal medicine 2015, 30(4), , pp.550-553
Main Authors: Lee, Na-Ri, Jang, Ji Won, Kim, Hee Sun, Yhim, Ho-Young
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container_title The Korean journal of internal medicine
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creator Lee, Na-Ri
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description In conclusion, we presented a rare case of ILD associated with IM therapy in a patient with GIST. It is important to have a high index of suspicion for this rare pulmonary toxicity when patients, in particular with preexisting lung disease, have unexplained lung infiltrates regardless of pulmonary symptoms if they are receiving the IM. The early evaluation with chest computed tomography and prompt withdrawal of IM with or without the use of corticosteroid is needed to avoid further detrimental effects of the drug. Furthermore, prospective study is needed to investigate the incidence of IM-induced ILD in patients with prior history of M. tuberculosis infection. KCI Citation Count: 4
doi_str_mv 10.3904/kjim.2015.30.4.550
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subjects Adult
Antineoplastic Agents - adverse effects
Antitubercular Agents - therapeutic use
Biopsy
Female
Gastrointestinal Stromal Tumors - drug therapy
Gastrointestinal Stromal Tumors - pathology
Gastrointestinal Stromal Tumors - surgery
Humans
Imatinib Mesylate - adverse effects
Letter to the Editor
Lung Diseases, Interstitial - chemically induced
Lung Diseases, Interstitial - diagnosis
Mycobacterium tuberculosis - isolation & purification
Protein Kinase Inhibitors - adverse effects
Rectal Neoplasms - drug therapy
Rectal Neoplasms - pathology
Rectal Neoplasms - surgery
Tomography, X-Ray Computed
Tuberculosis, Pulmonary - diagnosis
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - microbiology
내과학
title Imatinib mesylate-induced interstitial lung disease in a patient with prior history of Mycobacterium tuberculosis infection
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