Comparison of the 13C-urea breath test and the endoscopic phenol red mucosal pH test in the quantification of Helicobacter pylori infection loading

The (13)C-urea breath test (UBT) is a semiquantitative test for measuring Helicobacter pylori infection loading. H. pylori produces ammonia, which elevates the pH of the gastric mucosa and is detectable via endoscopy using a phenol red indicator. We evaluated whether this test could be used to diagn...

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Bibliographic Details
Published in:The Korean journal of internal medicine 2008, 23(3), , pp.134-139
Main Authors: Cho, Young-Seok, Chae, Hiun-Suk, Jang, Se Na, Kim, Jin-Soo, Son, Hye Suk, Kim, Hyung-Keun, Kim, Byung-Wook, Han, Sok-Won, Choi, Kyu-Yong, Lee, Hae Kyung, Chang, Eun Deok
Format: Article
Language:English
Subjects:
Adult
Aged
Breath Tests
Clinical Enzyme Tests
Endoscopy, Gastrointestinal
Esophageal pH Monitoring
Female
Gastric Mucosa - pathology
Helicobacter Infections - diagnosis
Helicobacter pylori - isolation & purification
Humans
Male
Middle Aged
Original
Phenolsulfonphthalein
Urease
내과학
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Summary:The (13)C-urea breath test (UBT) is a semiquantitative test for measuring Helicobacter pylori infection loading. H. pylori produces ammonia, which elevates the pH of the gastric mucosa and is detectable via endoscopy using a phenol red indicator. We evaluated whether this test could be used to diagnose H. pylori infection and whether phenol red staining was correlated with (13)C-UBT results. One hundred and twenty-three patients participated. The UBT was performed after ingestion of a capsule containing urea. A change in (13)C-UBT >2 ppt was selected as the cutoff value for diagnosing infection. After spraying evenly with a 0.1% phenol red solution, the pH of the gastric mucosal surface was measured using an antimony electrode through the biopsy channel. The pH of stained mucosa (6.9+/-0.4) was significantly higher than that of unstained mucosa (1.9+/-0.8; p
ISSN:1226-3303
2005-6648
DOI:10.3904/kjim.2008.23.3.134