Multiple Roles of Peroxiredoxins in Inflammation

Inflammation is a pathophysiological response to infection or tissue damage during which high levels of reactive oxygen and nitrogen species are produced by phagocytes to kill microorganisms. Reactive oxygen and nitrogen species serve also in the complex regulation of inflammatory processes. Recentl...

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Bibliographic Details
Published in:Molecules and cells 2016, 39(1), , pp.60-64
Main Authors: Knoops, Bernard, Argyropoulou, Vasiliki, Becker, Sarah, Ferté, Laura, Kuznetsova, Oksana
Format: Article
Language:English
Subjects:
Animals
Humans
Inflammation - enzymology
Minireview
Oxidative Stress
Peroxides - metabolism
Peroxiredoxins - metabolism
Peroxynitrous Acid - metabolism
Signal Transduction
생물학
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Summary:Inflammation is a pathophysiological response to infection or tissue damage during which high levels of reactive oxygen and nitrogen species are produced by phagocytes to kill microorganisms. Reactive oxygen and nitrogen species serve also in the complex regulation of inflammatory processes. Recently, it has been proposed that peroxiredoxins may play key roles in innate immunity and inflammation. Indeed, peroxiredoxins are evolutionarily conserved peroxidases able to reduce, with high rate constants, hydrogen peroxide, alkyl hydroperoxides and peroxynitrite which are generated during inflammation. In this minireview, we point out different possible roles of peroxiredoxins during inflammatory processes such as cytoprotective enzymes against oxidative stress, modulators of redox signaling, and extracellular pathogen- or damage-associated molecular patterns. A better understanding of peroxiredoxin functions in inflammation could lead to the discovery of new therapeutic targets.
ISSN:1016-8478
0219-1032
DOI:10.14348/molcells.2016.2341