Endothelial Aquaporin-1 (AQP1) Expression Is Regulated by Transcription Factor Mef2c

Aquaporin 1 (AQP1) is expressed in most microvasculature endothelial cells and forms water channels that play major roles in a variety of physiologic processes. This study aimed to delineate the transcriptional regulation of AQP1 by Mef2c in endothelial cells. Mef2c cooperated with Sp1 to activate h...

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Bibliographic Details
Published in:Molecules and cells 2016, 39(4), , pp.292-298
Main Authors: Jiang, Yong, Liu, He, Liu, Wen-Jing, Tong, Hai-Bin, Chen, Chang-Jun, Lin, Fu-Gui, Zhuo, Yan-Hang, Qian, Xiao-Zhen, Wang, Zeng-Bin, Wang, Yu, Zhang, Peng, Jia, Hong-Liang
Format: Article
Language:English
Subjects:
Aquaporin 1 - genetics
Cell Movement
Gene Expression Regulation
Human Umbilical Vein Endothelial Cells
Humans
MEF2 Transcription Factors - metabolism
Neovascularization, Physiologic
Promoter Regions, Genetic
Sp1 Transcription Factor - metabolism
생물학
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Summary:Aquaporin 1 (AQP1) is expressed in most microvasculature endothelial cells and forms water channels that play major roles in a variety of physiologic processes. This study aimed to delineate the transcriptional regulation of AQP1 by Mef2c in endothelial cells. Mef2c cooperated with Sp1 to activate human AQP1 transcription by binding to its proximal promoter in human umbilical cord vein endothelial cells (HUVEC). Over-expression of Mef2c, Sp1, or Mef2c/Sp1 increased HUVEC migration and tube-forming ability, which can be abolished AQP1 knockdown. These data indicate that AQP1 is a direct target of Mef2c in regulating angiogenesis and vasculogenesis of endothelial cells.
ISSN:1016-8478
0219-1032
DOI:10.14348/molcells.2016.2223