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Clinical application of liver MR imaging in Wilson's disease
To determine whether there is a correlation between liver MR findings and the clinical manifestations and severity of liver dysfunction in patients with Wilson's disease. Two radiologists retrospectively evaluated MR images of the liver in 50 patients with Wilson's disease. The Institution...
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Published in: | Korean journal of radiology 2010, 11(6), , pp.665-672 |
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creator | Cheon, Jung-Eun Kim, In-One Seo, Jeong Kee Ko, Jae Sung Lee, Jeong Min Shin, Cheong-Il Kim, Woo Sun Yeon, Kyung Mo |
description | To determine whether there is a correlation between liver MR findings and the clinical manifestations and severity of liver dysfunction in patients with Wilson's disease.
Two radiologists retrospectively evaluated MR images of the liver in 50 patients with Wilson's disease. The Institutional Review Board approved this retrospective study and informed consent was waived. MR images were evaluated with a focus on hepatic contour abnormalities and the presence of intrahepatic nodules. By using Fisher's exact test, MR findings were compared with clinical presentations (neurological and non-neurological) and hepatic dysfunction, which was categorized by the Child-Pugh classification system (A, B and C). Follow-up MR images were available for 17 patients.
Contour abnormalities of the liver and intrahepatic nodules were observed in 31 patients (62%) and 25 patients (50%), respectively. Each MR finding showed a statistically significant difference (p < 0.05) among the three groups of Child-Pugh classifications (A, n = 36; B, n = 5; C, n = 9), except for splenomegaly (p = 0.243). The mean age of the patients with positive MR findings was higher than that of patients with negative MR findings. For patients with Child-Pugh class A (n = 36) with neurological presentation, intrahepatic nodules, surface nodularity, and gallbladder fossa widening were more common. Intrahepatic nodules were improved (n = 8, 47%), stationary (n = 5, 29%), or aggravated (n = 4, 24%) on follow-up MR images.
MR imaging demonstrates the contour abnormalities and parenchymal nodules of the liver in more than half of the patients with Wilson's disease, which correlates with the severity of hepatic dysfunction and clinical manifestations. |
doi_str_mv | 10.3348/kjr.2010.11.6.665 |
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Two radiologists retrospectively evaluated MR images of the liver in 50 patients with Wilson's disease. The Institutional Review Board approved this retrospective study and informed consent was waived. MR images were evaluated with a focus on hepatic contour abnormalities and the presence of intrahepatic nodules. By using Fisher's exact test, MR findings were compared with clinical presentations (neurological and non-neurological) and hepatic dysfunction, which was categorized by the Child-Pugh classification system (A, B and C). Follow-up MR images were available for 17 patients.
Contour abnormalities of the liver and intrahepatic nodules were observed in 31 patients (62%) and 25 patients (50%), respectively. Each MR finding showed a statistically significant difference (p < 0.05) among the three groups of Child-Pugh classifications (A, n = 36; B, n = 5; C, n = 9), except for splenomegaly (p = 0.243). The mean age of the patients with positive MR findings was higher than that of patients with negative MR findings. For patients with Child-Pugh class A (n = 36) with neurological presentation, intrahepatic nodules, surface nodularity, and gallbladder fossa widening were more common. Intrahepatic nodules were improved (n = 8, 47%), stationary (n = 5, 29%), or aggravated (n = 4, 24%) on follow-up MR images.
MR imaging demonstrates the contour abnormalities and parenchymal nodules of the liver in more than half of the patients with Wilson's disease, which correlates with the severity of hepatic dysfunction and clinical manifestations.</description><identifier>ISSN: 1229-6929</identifier><identifier>EISSN: 2005-8330</identifier><identifier>DOI: 10.3348/kjr.2010.11.6.665</identifier><identifier>PMID: 21076593</identifier><language>eng</language><publisher>Korea (South): The Korean Society of Radiology</publisher><subject>Adolescent ; Adult ; Age ; Ascites ; Asymptomatic ; Chelating agents ; Chi-Square Distribution ; Child ; Child, Preschool ; Female ; Gallbladder ; Hepatitis ; Hepatolenticular Degeneration - diagnosis ; Hepatolenticular Degeneration - pathology ; Humans ; Image Interpretation, Computer-Assisted ; Liver ; Magnetic Resonance Imaging - methods ; Male ; Original ; Patients ; Retrospective Studies ; Statistics, Nonparametric ; 방사선과학</subject><ispartof>Korean Journal of Radiology, 2010, 11(6), , pp.665-672</ispartof><rights>2010. This work is published under http://creativecommons.org/licenses/by-nc/3.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2010 The Korean Society of Radiology 2010</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-a263d75da9c0af00f2b2160671e8a904fe70098611cbc672862ffa2ff8c4d0fb3</citedby><cites>FETCH-LOGICAL-c459t-a263d75da9c0af00f2b2160671e8a904fe70098611cbc672862ffa2ff8c4d0fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2728301907/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2728301907?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21076593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001499952$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheon, Jung-Eun</creatorcontrib><creatorcontrib>Kim, In-One</creatorcontrib><creatorcontrib>Seo, Jeong Kee</creatorcontrib><creatorcontrib>Ko, Jae Sung</creatorcontrib><creatorcontrib>Lee, Jeong Min</creatorcontrib><creatorcontrib>Shin, Cheong-Il</creatorcontrib><creatorcontrib>Kim, Woo Sun</creatorcontrib><creatorcontrib>Yeon, Kyung Mo</creatorcontrib><title>Clinical application of liver MR imaging in Wilson's disease</title><title>Korean journal of radiology</title><addtitle>Korean J Radiol</addtitle><description>To determine whether there is a correlation between liver MR findings and the clinical manifestations and severity of liver dysfunction in patients with Wilson's disease.
Two radiologists retrospectively evaluated MR images of the liver in 50 patients with Wilson's disease. The Institutional Review Board approved this retrospective study and informed consent was waived. MR images were evaluated with a focus on hepatic contour abnormalities and the presence of intrahepatic nodules. By using Fisher's exact test, MR findings were compared with clinical presentations (neurological and non-neurological) and hepatic dysfunction, which was categorized by the Child-Pugh classification system (A, B and C). Follow-up MR images were available for 17 patients.
Contour abnormalities of the liver and intrahepatic nodules were observed in 31 patients (62%) and 25 patients (50%), respectively. Each MR finding showed a statistically significant difference (p < 0.05) among the three groups of Child-Pugh classifications (A, n = 36; B, n = 5; C, n = 9), except for splenomegaly (p = 0.243). The mean age of the patients with positive MR findings was higher than that of patients with negative MR findings. For patients with Child-Pugh class A (n = 36) with neurological presentation, intrahepatic nodules, surface nodularity, and gallbladder fossa widening were more common. Intrahepatic nodules were improved (n = 8, 47%), stationary (n = 5, 29%), or aggravated (n = 4, 24%) on follow-up MR images.
MR imaging demonstrates the contour abnormalities and parenchymal nodules of the liver in more than half of the patients with Wilson's disease, which correlates with the severity of hepatic dysfunction and clinical manifestations.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Ascites</subject><subject>Asymptomatic</subject><subject>Chelating agents</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Gallbladder</subject><subject>Hepatitis</subject><subject>Hepatolenticular Degeneration - diagnosis</subject><subject>Hepatolenticular Degeneration - pathology</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Liver</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Original</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Statistics, Nonparametric</subject><subject>방사선과학</subject><issn>1229-6929</issn><issn>2005-8330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkU9rGzEQxUVoaRynHyCXstBDcllnJO1KKyiFYJo_kBAIKT0KWSu5smXJlWxDv31kOzFpD2Ik9JvHvHkInWEYUdp0l_NZGhEoL4xHbMRYe4QGBKCtO0rhAxpgQkTNBBHH6CTnGQAR0DWf0DHBwFkr6AB9G3sXnFa-UsulL5eVi6GKtvJuY1L18FS5hZq6MK1cqH45n2M4z1XvslHZnKKPVvlsPr_WIfp5_eN5fFvfP97cja_ua920YlUrwmjP214JDcoCWDIhmAHj2HRKQGMNBxAdw1hPNOOkY8RaVU6nmx7shA7RxV43JCvn2smo3K5Oo5wnefX0fCd5UeSsoN_36HI9WZhem7BKystlKjbS313jvz_B_S4yG0kEb8q6isD5q0CKf9Ymr-TCZW28V8HEdZa849DQBrbk1__IWVynUBYhSTFBAQvghcJ7SqeYczL2MAsGuU1RlhTlNkWJsWSypFh6vrw3ceh4i42-ALYyl7s</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Cheon, Jung-Eun</creator><creator>Kim, In-One</creator><creator>Seo, Jeong Kee</creator><creator>Ko, Jae Sung</creator><creator>Lee, Jeong Min</creator><creator>Shin, Cheong-Il</creator><creator>Kim, Woo Sun</creator><creator>Yeon, Kyung Mo</creator><general>The Korean Society of Radiology</general><general>대한영상의학회</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>ACYCR</scope></search><sort><creationdate>20101101</creationdate><title>Clinical application of liver MR imaging in Wilson's disease</title><author>Cheon, Jung-Eun ; Kim, In-One ; Seo, Jeong Kee ; Ko, Jae Sung ; Lee, Jeong Min ; Shin, Cheong-Il ; Kim, Woo Sun ; Yeon, Kyung Mo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-a263d75da9c0af00f2b2160671e8a904fe70098611cbc672862ffa2ff8c4d0fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Ascites</topic><topic>Asymptomatic</topic><topic>Chelating agents</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Gallbladder</topic><topic>Hepatitis</topic><topic>Hepatolenticular Degeneration - diagnosis</topic><topic>Hepatolenticular Degeneration - pathology</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Liver</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Original</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Statistics, Nonparametric</topic><topic>방사선과학</topic><toplevel>online_resources</toplevel><creatorcontrib>Cheon, Jung-Eun</creatorcontrib><creatorcontrib>Kim, In-One</creatorcontrib><creatorcontrib>Seo, Jeong Kee</creatorcontrib><creatorcontrib>Ko, Jae Sung</creatorcontrib><creatorcontrib>Lee, Jeong Min</creatorcontrib><creatorcontrib>Shin, Cheong-Il</creatorcontrib><creatorcontrib>Kim, Woo Sun</creatorcontrib><creatorcontrib>Yeon, Kyung Mo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Korean Citation Index</collection><jtitle>Korean journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheon, Jung-Eun</au><au>Kim, In-One</au><au>Seo, Jeong Kee</au><au>Ko, Jae Sung</au><au>Lee, Jeong Min</au><au>Shin, Cheong-Il</au><au>Kim, Woo Sun</au><au>Yeon, Kyung Mo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical application of liver MR imaging in Wilson's disease</atitle><jtitle>Korean journal of radiology</jtitle><addtitle>Korean J Radiol</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>11</volume><issue>6</issue><spage>665</spage><epage>672</epage><pages>665-672</pages><issn>1229-6929</issn><eissn>2005-8330</eissn><abstract>To determine whether there is a correlation between liver MR findings and the clinical manifestations and severity of liver dysfunction in patients with Wilson's disease.
Two radiologists retrospectively evaluated MR images of the liver in 50 patients with Wilson's disease. The Institutional Review Board approved this retrospective study and informed consent was waived. MR images were evaluated with a focus on hepatic contour abnormalities and the presence of intrahepatic nodules. By using Fisher's exact test, MR findings were compared with clinical presentations (neurological and non-neurological) and hepatic dysfunction, which was categorized by the Child-Pugh classification system (A, B and C). Follow-up MR images were available for 17 patients.
Contour abnormalities of the liver and intrahepatic nodules were observed in 31 patients (62%) and 25 patients (50%), respectively. Each MR finding showed a statistically significant difference (p < 0.05) among the three groups of Child-Pugh classifications (A, n = 36; B, n = 5; C, n = 9), except for splenomegaly (p = 0.243). The mean age of the patients with positive MR findings was higher than that of patients with negative MR findings. For patients with Child-Pugh class A (n = 36) with neurological presentation, intrahepatic nodules, surface nodularity, and gallbladder fossa widening were more common. Intrahepatic nodules were improved (n = 8, 47%), stationary (n = 5, 29%), or aggravated (n = 4, 24%) on follow-up MR images.
MR imaging demonstrates the contour abnormalities and parenchymal nodules of the liver in more than half of the patients with Wilson's disease, which correlates with the severity of hepatic dysfunction and clinical manifestations.</abstract><cop>Korea (South)</cop><pub>The Korean Society of Radiology</pub><pmid>21076593</pmid><doi>10.3348/kjr.2010.11.6.665</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Age Ascites Asymptomatic Chelating agents Chi-Square Distribution Child Child, Preschool Female Gallbladder Hepatitis Hepatolenticular Degeneration - diagnosis Hepatolenticular Degeneration - pathology Humans Image Interpretation, Computer-Assisted Liver Magnetic Resonance Imaging - methods Male Original Patients Retrospective Studies Statistics, Nonparametric 방사선과학 |
title | Clinical application of liver MR imaging in Wilson's disease |
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