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Clinical application of liver MR imaging in Wilson's disease

To determine whether there is a correlation between liver MR findings and the clinical manifestations and severity of liver dysfunction in patients with Wilson's disease. Two radiologists retrospectively evaluated MR images of the liver in 50 patients with Wilson's disease. The Institution...

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Published in:Korean journal of radiology 2010, 11(6), , pp.665-672
Main Authors: Cheon, Jung-Eun, Kim, In-One, Seo, Jeong Kee, Ko, Jae Sung, Lee, Jeong Min, Shin, Cheong-Il, Kim, Woo Sun, Yeon, Kyung Mo
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description To determine whether there is a correlation between liver MR findings and the clinical manifestations and severity of liver dysfunction in patients with Wilson's disease. Two radiologists retrospectively evaluated MR images of the liver in 50 patients with Wilson's disease. The Institutional Review Board approved this retrospective study and informed consent was waived. MR images were evaluated with a focus on hepatic contour abnormalities and the presence of intrahepatic nodules. By using Fisher's exact test, MR findings were compared with clinical presentations (neurological and non-neurological) and hepatic dysfunction, which was categorized by the Child-Pugh classification system (A, B and C). Follow-up MR images were available for 17 patients. Contour abnormalities of the liver and intrahepatic nodules were observed in 31 patients (62%) and 25 patients (50%), respectively. Each MR finding showed a statistically significant difference (p < 0.05) among the three groups of Child-Pugh classifications (A, n = 36; B, n = 5; C, n = 9), except for splenomegaly (p = 0.243). The mean age of the patients with positive MR findings was higher than that of patients with negative MR findings. For patients with Child-Pugh class A (n = 36) with neurological presentation, intrahepatic nodules, surface nodularity, and gallbladder fossa widening were more common. Intrahepatic nodules were improved (n = 8, 47%), stationary (n = 5, 29%), or aggravated (n = 4, 24%) on follow-up MR images. MR imaging demonstrates the contour abnormalities and parenchymal nodules of the liver in more than half of the patients with Wilson's disease, which correlates with the severity of hepatic dysfunction and clinical manifestations.
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subjects Adolescent
Adult
Age
Ascites
Asymptomatic
Chelating agents
Chi-Square Distribution
Child
Child, Preschool
Female
Gallbladder
Hepatitis
Hepatolenticular Degeneration - diagnosis
Hepatolenticular Degeneration - pathology
Humans
Image Interpretation, Computer-Assisted
Liver
Magnetic Resonance Imaging - methods
Male
Original
Patients
Retrospective Studies
Statistics, Nonparametric
방사선과학
title Clinical application of liver MR imaging in Wilson's disease
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