Impact of retrotransposons in pluripotent stem cells

Retrotransposons, which constitute approximately 40% of the human genome, have the capacity to 'jump' across the genome. Their mobility contributes to oncogenesis, evolution, and genomic plasticity of the host genome. Induced pluripotent stem cells as well as embryonic stem cells are more...

Full description

Saved in:
Bibliographic Details
Published in:Molecules and cells 2012, 34(6), , pp.509-516
Main Authors: Tanaka, Yoshiaki, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA, Chung, Leeyup, Duke University Medical Center, Durham, NC, USA, Park, I.H., Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA
Format: Article
Language:English
Subjects:
Alu
Alu Elements
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cell Biology
Cell Differentiation
Embryonic Stem Cells - metabolism
GENOMAS
GENOME
Genome, Human
GENOMES
Humans
Induced Pluripotent Stem Cells - metabolism
Life Sciences
LTR retrotransposon
Minireview
pluripotent stem cell
Pluripotent Stem Cells - metabolism
Retroelements
SVA
생물학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c594t-d7f3df69ac1f65ac908ff25c54805026833435beaa47f12384cdb706b6c1dbf03
cites cdi_FETCH-LOGICAL-c594t-d7f3df69ac1f65ac908ff25c54805026833435beaa47f12384cdb706b6c1dbf03
container_end_page 516
container_issue 6
container_start_page 509
container_title Molecules and cells
container_volume 34
creator Tanaka, Yoshiaki, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA
Chung, Leeyup, Duke University Medical Center, Durham, NC, USA
Park, I.H., Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA
description Retrotransposons, which constitute approximately 40% of the human genome, have the capacity to 'jump' across the genome. Their mobility contributes to oncogenesis, evolution, and genomic plasticity of the host genome. Induced pluripotent stem cells as well as embryonic stem cells are more susceptible than differentiated cells to genomic aberrations including insertion, deletion and duplication. Recent studies have revealed specific behaviors of retrotransposons in pluripotent cells. Here, we review recent progress in understanding retrotransposons and provide a perspective on the relationship between retrotransposons and genomic variation in pluripotent stem cells.
doi_str_mv 10.1007/s10059-012-0242-8
format article
fullrecord <record><control><sourceid>proquest_nrf_k</sourceid><recordid>TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_71704</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1273462088</sourcerecordid><originalsourceid>FETCH-LOGICAL-c594t-d7f3df69ac1f65ac908ff25c54805026833435beaa47f12384cdb706b6c1dbf03</originalsourceid><addsrcrecordid>eNp9kkFv1jAMhiMEYh-DH8ABVIkDXAp2kibpBWma2PjEJKRpnKM0TT66tU1JWiT-Pek6psGBS3zw4ze2XxPyEuE9AsgPKb9VXQLSEiinpXpEdkCxLhEYfUx2CChKxaU6Is9SugZAKah6So4oQ1YJJnaE74fJ2LkIvohujmGOZkxTSGFMRTcWU7_EbgqzG-cizW4orOv79Jw88aZP7sVdPCbfzj5dnX4uL76e709PLkpb1XwuW-lZ60VtLHpRGVuD8p5WtuIKKqBCMcZZ1ThjuPRImeK2bSSIRlhsGw_smLzddMfo9Y3tdDDdbTwEfRP1yeXVXkuUwDP5cSOnpRlca3O_0fR6it1g4q_bur8zY_c9q_zUTCrOqMgC7-4EYvixuDTroUvrsGZ0YUkaqWRcUFAqo2_-Qa_DEse8CI0caZWXq1ZB3CgbQ0rR-ftmEPTqnt7c09k9vbqnV-XXD6e4r_hjVwboBqScGg8uPvj6P6qvtiJvgjaH2CX95ZICsnwPKu_uN_vGrQ8</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1412523186</pqid></control><display><type>article</type><title>Impact of retrotransposons in pluripotent stem cells</title><source>Open Access: PubMed Central</source><source>ScienceDirect (Online service)</source><creator>Tanaka, Yoshiaki, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA ; Chung, Leeyup, Duke University Medical Center, Durham, NC, USA ; Park, I.H., Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA</creator><creatorcontrib>Tanaka, Yoshiaki, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA ; Chung, Leeyup, Duke University Medical Center, Durham, NC, USA ; Park, I.H., Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA</creatorcontrib><description>Retrotransposons, which constitute approximately 40% of the human genome, have the capacity to 'jump' across the genome. Their mobility contributes to oncogenesis, evolution, and genomic plasticity of the host genome. Induced pluripotent stem cells as well as embryonic stem cells are more susceptible than differentiated cells to genomic aberrations including insertion, deletion and duplication. Recent studies have revealed specific behaviors of retrotransposons in pluripotent cells. Here, we review recent progress in understanding retrotransposons and provide a perspective on the relationship between retrotransposons and genomic variation in pluripotent stem cells.</description><identifier>ISSN: 1016-8478</identifier><identifier>EISSN: 0219-1032</identifier><identifier>DOI: 10.1007/s10059-012-0242-8</identifier><identifier>PMID: 23135636</identifier><language>eng</language><publisher>Springer: Korean Society for Molecular and Cellular Biology</publisher><subject>Alu ; Alu Elements ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Cell Biology ; Cell Differentiation ; Embryonic Stem Cells - metabolism ; GENOMAS ; GENOME ; Genome, Human ; GENOMES ; Humans ; Induced Pluripotent Stem Cells - metabolism ; Life Sciences ; LTR retrotransposon ; Minireview ; pluripotent stem cell ; Pluripotent Stem Cells - metabolism ; Retroelements ; SVA ; 생물학</subject><ispartof>Molecules and Cells, 2012, 34(6), , pp.509-516</ispartof><rights>The Korean Society for Molecular and Cellular Biology and Springer Netherlands 2012</rights><rights>The Korean Society for Molecular and Cellular Biology. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c594t-d7f3df69ac1f65ac908ff25c54805026833435beaa47f12384cdb706b6c1dbf03</citedby><cites>FETCH-LOGICAL-c594t-d7f3df69ac1f65ac908ff25c54805026833435beaa47f12384cdb706b6c1dbf03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784326/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784326/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23135636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001718050$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Yoshiaki, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA</creatorcontrib><creatorcontrib>Chung, Leeyup, Duke University Medical Center, Durham, NC, USA</creatorcontrib><creatorcontrib>Park, I.H., Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA</creatorcontrib><title>Impact of retrotransposons in pluripotent stem cells</title><title>Molecules and cells</title><addtitle>Mol Cells</addtitle><addtitle>Mol Cells</addtitle><description>Retrotransposons, which constitute approximately 40% of the human genome, have the capacity to 'jump' across the genome. Their mobility contributes to oncogenesis, evolution, and genomic plasticity of the host genome. Induced pluripotent stem cells as well as embryonic stem cells are more susceptible than differentiated cells to genomic aberrations including insertion, deletion and duplication. Recent studies have revealed specific behaviors of retrotransposons in pluripotent cells. Here, we review recent progress in understanding retrotransposons and provide a perspective on the relationship between retrotransposons and genomic variation in pluripotent stem cells.</description><subject>Alu</subject><subject>Alu Elements</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Cell Biology</subject><subject>Cell Differentiation</subject><subject>Embryonic Stem Cells - metabolism</subject><subject>GENOMAS</subject><subject>GENOME</subject><subject>Genome, Human</subject><subject>GENOMES</subject><subject>Humans</subject><subject>Induced Pluripotent Stem Cells - metabolism</subject><subject>Life Sciences</subject><subject>LTR retrotransposon</subject><subject>Minireview</subject><subject>pluripotent stem cell</subject><subject>Pluripotent Stem Cells - metabolism</subject><subject>Retroelements</subject><subject>SVA</subject><subject>생물학</subject><issn>1016-8478</issn><issn>0219-1032</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kkFv1jAMhiMEYh-DH8ABVIkDXAp2kibpBWma2PjEJKRpnKM0TT66tU1JWiT-Pek6psGBS3zw4ze2XxPyEuE9AsgPKb9VXQLSEiinpXpEdkCxLhEYfUx2CChKxaU6Is9SugZAKah6So4oQ1YJJnaE74fJ2LkIvohujmGOZkxTSGFMRTcWU7_EbgqzG-cizW4orOv79Jw88aZP7sVdPCbfzj5dnX4uL76e709PLkpb1XwuW-lZ60VtLHpRGVuD8p5WtuIKKqBCMcZZ1ThjuPRImeK2bSSIRlhsGw_smLzddMfo9Y3tdDDdbTwEfRP1yeXVXkuUwDP5cSOnpRlca3O_0fR6it1g4q_bur8zY_c9q_zUTCrOqMgC7-4EYvixuDTroUvrsGZ0YUkaqWRcUFAqo2_-Qa_DEse8CI0caZWXq1ZB3CgbQ0rR-ftmEPTqnt7c09k9vbqnV-XXD6e4r_hjVwboBqScGg8uPvj6P6qvtiJvgjaH2CX95ZICsnwPKu_uN_vGrQ8</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Tanaka, Yoshiaki, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA</creator><creator>Chung, Leeyup, Duke University Medical Center, Durham, NC, USA</creator><creator>Park, I.H., Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA</creator><general>Korean Society for Molecular and Cellular Biology</general><general>Korea Society for Molecular and Cellular Biology</general><general>한국분자세포생물학회</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>ACYCR</scope></search><sort><creationdate>20121201</creationdate><title>Impact of retrotransposons in pluripotent stem cells</title><author>Tanaka, Yoshiaki, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA ; Chung, Leeyup, Duke University Medical Center, Durham, NC, USA ; Park, I.H., Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-d7f3df69ac1f65ac908ff25c54805026833435beaa47f12384cdb706b6c1dbf03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alu</topic><topic>Alu Elements</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Cell Biology</topic><topic>Cell Differentiation</topic><topic>Embryonic Stem Cells - metabolism</topic><topic>GENOMAS</topic><topic>GENOME</topic><topic>Genome, Human</topic><topic>GENOMES</topic><topic>Humans</topic><topic>Induced Pluripotent Stem Cells - metabolism</topic><topic>Life Sciences</topic><topic>LTR retrotransposon</topic><topic>Minireview</topic><topic>pluripotent stem cell</topic><topic>Pluripotent Stem Cells - metabolism</topic><topic>Retroelements</topic><topic>SVA</topic><topic>생물학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Yoshiaki, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA</creatorcontrib><creatorcontrib>Chung, Leeyup, Duke University Medical Center, Durham, NC, USA</creatorcontrib><creatorcontrib>Park, I.H., Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest - Health &amp; Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>East &amp; South Asia Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Korean Citation Index (Open Access)</collection><jtitle>Molecules and cells</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Yoshiaki, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA</au><au>Chung, Leeyup, Duke University Medical Center, Durham, NC, USA</au><au>Park, I.H., Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of retrotransposons in pluripotent stem cells</atitle><jtitle>Molecules and cells</jtitle><stitle>Mol Cells</stitle><addtitle>Mol Cells</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>34</volume><issue>6</issue><spage>509</spage><epage>516</epage><pages>509-516</pages><issn>1016-8478</issn><eissn>0219-1032</eissn><abstract>Retrotransposons, which constitute approximately 40% of the human genome, have the capacity to 'jump' across the genome. Their mobility contributes to oncogenesis, evolution, and genomic plasticity of the host genome. Induced pluripotent stem cells as well as embryonic stem cells are more susceptible than differentiated cells to genomic aberrations including insertion, deletion and duplication. Recent studies have revealed specific behaviors of retrotransposons in pluripotent cells. Here, we review recent progress in understanding retrotransposons and provide a perspective on the relationship between retrotransposons and genomic variation in pluripotent stem cells.</abstract><cop>Springer</cop><pub>Korean Society for Molecular and Cellular Biology</pub><pmid>23135636</pmid><doi>10.1007/s10059-012-0242-8</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1016-8478
ispartof Molecules and Cells, 2012, 34(6), , pp.509-516
issn 1016-8478
0219-1032
language eng
recordid cdi_nrf_kci_oai_kci_go_kr_ARTI_71704
source Open Access: PubMed Central; ScienceDirect (Online service)
subjects Alu
Alu Elements
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cell Biology
Cell Differentiation
Embryonic Stem Cells - metabolism
GENOMAS
GENOME
Genome, Human
GENOMES
Humans
Induced Pluripotent Stem Cells - metabolism
Life Sciences
LTR retrotransposon
Minireview
pluripotent stem cell
Pluripotent Stem Cells - metabolism
Retroelements
SVA
생물학
title Impact of retrotransposons in pluripotent stem cells
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T09%3A35%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_nrf_k&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20retrotransposons%20in%20pluripotent%20stem%20cells&rft.jtitle=Molecules%20and%20cells&rft.au=Tanaka,%20Yoshiaki,%20Yale%20Stem%20Cell%20Center,%20Yale%20School%20of%20Medicine,%20New%20Haven,%20CT,%20USA&rft.date=2012-12-01&rft.volume=34&rft.issue=6&rft.spage=509&rft.epage=516&rft.pages=509-516&rft.issn=1016-8478&rft.eissn=0219-1032&rft_id=info:doi/10.1007/s10059-012-0242-8&rft_dat=%3Cproquest_nrf_k%3E1273462088%3C/proquest_nrf_k%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c594t-d7f3df69ac1f65ac908ff25c54805026833435beaa47f12384cdb706b6c1dbf03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1412523186&rft_id=info:pmid/23135636&rfr_iscdi=true