Inonotus obliquus Protects against Oxidative Stress-Induced Apoptosis and Premature Senescence

In this study, we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence. Pretreatment with I. obliquus scavenged intracellular ROS and prevented lipid peroxidation in hydrogen peroxide-treated human fibroblasts. As a result,...

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Bibliographic Details
Published in:Molecules and cells 2011, 31(5), , pp.423-429
Main Authors: Yun, J.S., Kangwon National University, Chuncheon, Republic of Korea, Pahk, J.W., Kangwon National University, Chuncheon, Republic of Korea, Lee, J.S., Kangwon National University, Chuncheon, Republic of Korea, Shin, W.C., Kangwon National University, Chuncheon, Republic of Korea, Lee, S.Y., Kangwon National University, Chuncheon, Republic of Korea, Hong, E.K., Kangwon National University, Chuncheon, Republic of Korea
Format: Article
Language:English
Subjects:
Animals
ANTIOXIDANTES
ANTIOXIDANTS
Antioxidants - chemistry
Antioxidants - pharmacology
ANTIOXYDANT
APOPTOSE
APOPTOSIS
Apoptosis - drug effects
Basidiomycota - chemistry
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cell Biology
Cell Survival - drug effects
Cellular Senescence - drug effects
ESPECIES DE OXIGENO REACTIVO
Female
Humans
Hydrogen Peroxide - pharmacology
Inonotus obliquus
Life Sciences
Lipid Peroxidation - drug effects
Mice
Mice, Hairless
Molecules and Cells
Oxidative Stress - drug effects
REACTIVE OXYGEN SPECIES
Reactive Oxygen Species - metabolism
stress-induced premature senescence
생물학
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Summary:In this study, we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence. Pretreatment with I. obliquus scavenged intracellular ROS and prevented lipid peroxidation in hydrogen peroxide-treated human fibroblasts. As a result, I. obliquus exerted protective effects against hydrogen peroxide-induced apoptosis and premature senescence in human fibroblasts. In addition, I. obliquus suppressed UV-induced morphologic skin changes, such as skin thickening and wrinkle formation, in hairless mice in vivo and increased collagen synthesis through inhibition of MMP-1 and MMP-9 activities in hydrogen peroxide-treated human fibroblasts. Taken together, these results demonstrate that I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senescence.
ISSN:1016-8478
0219-1032
DOI:10.1007/s10059-011-0256-7