Nanomaterials for Cancer Therapy and Imaging

A variety of organic and inorganic nanomaterials with dimensions below several hundred nanometers are recently emerging as promising tools for cancer therapeutic and diagnostic applications due to their unique characteristics of passive tumor targeting. A wide range of nanomedicine platforms such as...

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Bibliographic Details
Published in:Molecules and cells 2011, 31(4), , pp.295-302
Main Authors: Bae, K.H., Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, Chung, H.J., Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, Park, T.G., Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
cancer therapy
Cell Biology
Contrast Media - chemistry
Contrast Media - pharmacokinetics
Diagnostic Imaging - methods
Drug Carriers - chemistry
Drug Carriers - pharmacokinetics
Drug Carriers - therapeutic use
drug delivery system
Humans
imaging
Life Sciences
Minireview
nanoparticles
Nanostructures - therapeutic use
NEOPLASMAS
NEOPLASME
NEOPLASMS
Neoplasms - blood supply
Neoplasms - drug therapy
Neoplasms - physiopathology
RNA Interference
small interfering RNA
생물학
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Summary:A variety of organic and inorganic nanomaterials with dimensions below several hundred nanometers are recently emerging as promising tools for cancer therapeutic and diagnostic applications due to their unique characteristics of passive tumor targeting. A wide range of nanomedicine platforms such as polymeric micelles, liposomes, dendrimers, and polymeric nanoparticles have been extensively explored for targeted delivery of anti-cancer agents, because they can accumulate in the solid tumor site via leaky tumor vascular structures, thereby selectively delivering therapeutic payloads into the desired tumor tissue. In recent years, nanoscale delivery vehicles for small interfering RNA (siRNA) have been also developed as effective therapeutic approaches to treat cancer. Furthermore, rationally designed multi-functional surface modification of these nanomaterials with cancer targeting moieties, protective polymers, and imaging agents can lead to fabrication versatile theragnostic nanosystems that allow simultaneous cancer therapy and diagnosis. This review highlights the current state and future prospects of diverse biomedical nanomaterials for cancer therapy and imaging.
ISSN:1016-8478
0219-1032
DOI:10.1007/s10059-011-0051-5