Autophagy in viral replication and pathogenesis

Autophagy is a catabolic process that is important for the removal of damaged organelles and long-lived proteins for the maintenance of cellular homeostasis. It can also serve as innate immunity to remove intracellular microbial pathogens. A growing list of viruses has been shown to affect this cell...

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Bibliographic Details
Published in:Molecules and cells 2010, 29(1), , pp.1-7
Main Authors: Sir, Donna, Ou, Jing-hsiung James
Format: Article
Language:English
Subjects:
Animals
Autophagy
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cell Biology
Cell Survival
Host-Pathogen Interactions
Humans
Immunity, Innate
Life Sciences
Membrane Fusion
Minireview
Virus Diseases - immunology
Virus Diseases - pathology
Virus Diseases - virology
Virus Replication
생물학
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Summary:Autophagy is a catabolic process that is important for the removal of damaged organelles and long-lived proteins for the maintenance of cellular homeostasis. It can also serve as innate immunity to remove intracellular microbial pathogens. A growing list of viruses has been shown to affect this cellular pathway. Some viruses suppress this pathway for their survival, while others enhance or exploit this pathway to benefit their replication. The effect of viruses on autophagy may also sensitize cells to death or enhance cell survival and play a critical role in viral pathogenesis. In this article, we review the relationships between different viruses and autophagy and discuss how these relationships may affect viruses and their host cells.
ISSN:1016-8478
0219-1032
DOI:10.1007/s10059-010-0014-2