Anesthesia of a dental patient with Angelman syndrome -A case report

Angelman syndrome is characterized by a partial deficit of paired autosomal chromosome 15, which contains a subunit of the GABA (Gamma-Amino Butyric Acid) receptor. Many drugs that act on the CNS (Central Nerve System) during anesthesia are believed to exert their effects via the GABA receptors. We...

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Bibliographic Details
Published in:Korean journal of anesthesiology 2010, 58(2), , pp.207-210
Main Authors: Kim, Bo Sung, Yeo, Jin Seok, Kim, Si Oh
Format: Article
Language:English
Subjects:
anesthesia
angelman syndrome
Case Report
chromosome 15
gaba receptor
outpatient surgery
마취과학
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Summary:Angelman syndrome is characterized by a partial deficit of paired autosomal chromosome 15, which contains a subunit of the GABA (Gamma-Amino Butyric Acid) receptor. Many drugs that act on the CNS (Central Nerve System) during anesthesia are believed to exert their effects via the GABA receptors. We describe the anesthesia of a 7 year-old female patient with Angelman syndrome who underwent surgery for dental caries. The basic factors that needed to be considered when administering anesthesia to this patient were epilepsy, significant dominance of the vagal tone, craniofacial abnormalities and peripheral muscular atrophy. Inhalational anesthetics (sevoflurane) were employed for this patient. The patient had an uneventful peri-operative period and was discharged home on the same day of the operation.
ISSN:2005-6419
2005-7563
DOI:10.4097/kjae.2010.58.2.207