Activation of the Human Endogenous Retrovirus W Long Terminal Repeat by Herpes Simplex Virus Type 1 Immediate Early Protein 1

The U3 region of the human endogenous retrovirus W long terminal repeat (HERV-W LTR) contains several putative regulatory sequences that regulate the transcription of neighboring cellular genes, as well as viral genes. We found that the LTR-directed transcription of the HERV-W can be induced by the...

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Bibliographic Details
Published in:Molecules and cells 2003, 15(1), , pp.75-80
Main Authors: Lee, W.J, Kwun, H.J, Kim, H.S, Jang, K.L. (Pusan National University, Busan, Republic of Korea)
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular - pathology
CELLS
DNA - genetics
DNA - metabolism
DNA-Binding Proteins - metabolism
Endogenous Retroviruses - genetics
Genes, Immediate-Early
Genes, Reporter
Genes, Viral
HeLa Cells
Herpesvirus 1, Human - genetics
Herpesvirus 1, Human - physiology
Host Cell Factor C1
Humans
Immediate-Early Proteins - genetics
Immediate-Early Proteins - physiology
Liver Neoplasms - pathology
Luciferases - biosynthesis
Luciferases - genetics
Octamer Transcription Factor-1
Plasmids - genetics
Protein Binding
Reverse Transcriptase Polymerase Chain Reaction
Teratocarcinoma - pathology
Terminal Repeat Sequences
Transcription Factors - metabolism
Transcription, Genetic
Tumor Cells, Cultured
Viral Proteins - genetics
Viral Proteins - physiology
생물학
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Summary:The U3 region of the human endogenous retrovirus W long terminal repeat (HERV-W LTR) contains several putative regulatory sequences that regulate the transcription of neighboring cellular genes, as well as viral genes. We found that the LTR-directed transcription of the HERV-W can be induced by the herpes simplex virus type 1 (HSV-1) infection.
ISSN:1016-8478
0219-1032
DOI:10.1016/S1016-8478(23)13710-1