Scalarane-type Sesterterpenes from the Philippines Sponge Hyrtios sp

The marine sponge Hyrtios sp. collected in the Philippines was extracted and partitioned. The resulting organic layer was purified by C18 reversed-phase column chromatography and HPLC to achieve the separation of nine scalarane-type sesterterpenes, including one new compound with eight known scalara...

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Bibliographic Details
Published in:Ocean and polar research 2020, 42(1), , pp.15-20
Main Authors: Jae-Hyeong Choi, 이희승, Wilfredo L. Campos
Format: Article
Language:English
Subjects:
해양학
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Summary:The marine sponge Hyrtios sp. collected in the Philippines was extracted and partitioned. The resulting organic layer was purified by C18 reversed-phase column chromatography and HPLC to achieve the separation of nine scalarane-type sesterterpenes, including one new compound with eight known scalarane analogs. The chemical structures of the isolated compounds 1−9 were elucidated by 1D and 2D NMR and MS data analysis. All nine compounds were evaluated for their antibacterial activities against three Gram-positive and three Gram-negative bacteria. The compound 3 exhibited potent antibacterial activities against Bacillus subtilis and Micrococcus luteus. The compounds 7 and 9 displayed considerable activities against Bacillus subtilis and the others had moderate results. KCI Citation Count: 0
ISSN:1598-141X
2234-7313
DOI:10.4217/OPR.2020.42.1.015