The clinical outcomes of proton beam radiation therapy for retinoblastomas that were resistant to chemotherapy and focal treatment

To evaluate the clinical results of proton beam radiation therapy (PBRT) for treatment of retinoblastoma. Children with retinoblastoma who were treated with chemotherapy and focal treatment such as brachytherapy and thermotherapy but showed no response or developed recurrences later received PBRT. T...

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Bibliographic Details
Published in:Korean journal of ophthalmology 2011, 25(6), , pp.387-393
Main Authors: Chang, Ji Woong, Yu, Young Suk, Kim, Joo Young, Shin, Dong Ho, Choi, Jin, Kim, Jeong Hun, Kim, Seong-Joon
Format: Article
Language:English
Subjects:
Child, Preschool
Combined Modality Therapy
Drug Resistance
Female
Humans
Infant
Male
Original
Retinal Neoplasms - drug therapy
Retinal Neoplasms - radiotherapy
Retinal Neoplasms - surgery
Retinoblastoma - drug therapy
Retinoblastoma - radiotherapy
Retinoblastoma - surgery
Retrospective Studies
Treatment Outcome
안과학
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Summary:To evaluate the clinical results of proton beam radiation therapy (PBRT) for treatment of retinoblastoma. Children with retinoblastoma who were treated with chemotherapy and focal treatment such as brachytherapy and thermotherapy but showed no response or developed recurrences later received PBRT. The PBRT strategy was designed to concentrate the radiation energy to the retinoblastoma and spare the surrounding healthy tissue or organs. There were three patients who received PBRT. The first patient received PBRT because of an initial lack of tumor regression with chemotherapy and brachytherapy. This patient showed regression after PBRT. The second patient who developed recurrence of retinoblastoma as diffuse infiltrating subretinal seeding was taken PBRT. After complete regression, there was recurrence of tumor and the eye was enucleated. The third patient had unilateral extensively advanced retinoblastoma. Initial chemotherapy failed and tumor recurred. The tumor responded to PBRT and regressed significantly. However, the eye developed sudden multiple recurrences, so we had to perform enucleation. PBRT for retinoblastoma was effective in cases of showing no response to other treatment modalities. However, it should be carefully applied when there was recurrence of diffuse infiltrating subretinal seeding or extensively advanced retinoblastoma initially.
ISSN:1011-8942
2092-9382
DOI:10.3341/kjo.2011.25.6.387