Serum calcium and phosphorus levels in patients undergoing maintenance hemodialysis: A multicentre study in Korea

• Published in: Kidney research and clinical practice 2014, 33(1), , pp.52-57
• Main Authors: Kim, Gheun-Ho, Choi, Bum Soon, Cha, Dae Ryong, Chee, Dong Hyun, Hwang, Eunah, Kim, Hyung Wook, Chang, Jae Hyun, Kim, Joong-Kyung, Noh, Jung Woo, Joo, Kwon Wook, Lee, Sang Choel, Han, Sang-Woong, Kim, Sejoong, Kim, Soo Wan, Shin, Sug-Kyun, Park, Wondo, Kim, Won, Huh, Wooseong, Kwon, Young Joo, Kang, Young Sun
• Format: Article
• Language: English
• Subjects: Calcium; Hemodialysis; Intact parathyroid hormone; Nephrology; Original; Phosphorus; Secondary hyperparathyroidism; 내과학
• ISSN: 2211-9132; 2211-9140
• DOI: 10.1016/j.krcp.2013.12.003

Abstract Background In many countries, nephrologists follow clinical practice guidelines for mineral bone disorders to control secondary hyperparathyroidism (SHPT) associated with abnormal serum calcium (Ca) and phosphorus (P) levels in patients undergoing maintenance hemodialysis (MHD). The Kidney Disease Outcomes Quality Initiative (KDOQI) Guidelines have long been used in Korea, and this study was undertaken to investigate the current status of serum Ca and P control in MHD patients. Methods Data were collected from a total of 1,018 patients undergoing MHD without intercurrent illness, in 17 hemodialysis centers throughout the country. Serum levels of Ca, P, and intact parathyroid hormone (iPTH) were measured over 1 year, and the average values were retrospectively analyzed. Results Serum levels of Ca, P, and the Ca×P product were 9.1±0.7 mg/dL, 5.3±1.4 mg/dL, and 48.0±13.6 mg2 /dL2 , respectively. However, the percentages of patients with Ca, P, and Ca × P product levels within the KDOQI guideline ranges were 58.7%, 51.0%, and 70.7%, respectively. Of the 1,018 patients, 270 (26.5%) had iPTH >300 pg/mL (uncontrolled SHPT), whereas 435 patients (42.7%) showed iPTH