Two cases of idiopathic membranous nephropathy treated with rituximab

Abstract Idiopathic membranous nephropathy is a common cause of nephrotic syndrome, and has been reported as a cause of idiopathic primary glomerulonephropathy in up to 90% of patients. However, the treatment options remain controversial. We report two cases of idiopathic membranous nephropathy that...

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Published in:Kidney research and clinical practice 2013, 32(3), , pp.138-141
Main Authors: Young Yoon, Jae, Tae Han, Seung, Cho, Ajin, Ryoun Jang, Hye, Eun Lee, Jung, Huh, Wooseong, Joong Kim, Dae, Young Oh, Ha, Kim, Yoon-Goo
Format: Article
Language:English
Subjects:
Case Report
Idiopathic membranous nephropathy
Nephrology
Nephrotic syndrome
Proteinuria
Rituximab
내과학
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cited_by cdi_FETCH-LOGICAL-c609t-56fdc93b60e76297dc2ee2fabd74bb15f932a4d1bffab50a83b043013d26a0ed3
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container_title Kidney research and clinical practice
container_volume 32
creator Young Yoon, Jae
Tae Han, Seung
Cho, Ajin
Ryoun Jang, Hye
Eun Lee, Jung
Huh, Wooseong
Joong Kim, Dae
Young Oh, Ha
Kim, Yoon-Goo
description Abstract Idiopathic membranous nephropathy is a common cause of nephrotic syndrome, and has been reported as a cause of idiopathic primary glomerulonephropathy in up to 90% of patients. However, the treatment options remain controversial. We report two cases of idiopathic membranous nephropathy that were treated with rituximab. A 54-year-old man and a 64-year old man were admitted for rituximab therapy. They had previously been treated with combinations of immunosuppressive agents including cyclophosphamide, cyclosporine, mycophenolate, and steroids. However, the patients' heavy proteinuria was not resolved. Both patients received rituximab therapy, 2 weeks apart. After several months of follow-up and a second round of rituximab treatment for each patient, their proteinuria decreased and partial remission of disease was achieved in both patients.
doi_str_mv 10.1016/j.krcp.2013.06.003
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source PubMed (Medline); ScienceDirect Journals
subjects Case Report
Idiopathic membranous nephropathy
Nephrology
Nephrotic syndrome
Proteinuria
Rituximab
내과학
title Two cases of idiopathic membranous nephropathy treated with rituximab
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