Connecting Myokines and Metabolism

Skeletal muscle is the largest organ of the body in non-obese individuals and is now considered to be an endocrine organ. Hormones (myokines) secreted by skeletal muscle mediate communications between muscle and liver, adipose tissue, brain, and other organs. Myokines affect muscle mass and myofiber...

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Bibliographic Details
Published in:Endocrinology and metabolism (Seoul) 2015, 30(3), , pp.235-245
Main Authors: Ahima, Rexford S, Park, Hyeong Kyu
Format: Article
Language:English
Subjects:
Diabetes
Exercise
Metabolism
Muscle, skeletal
Myokine
Obesity
Review
내과학
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Summary:Skeletal muscle is the largest organ of the body in non-obese individuals and is now considered to be an endocrine organ. Hormones (myokines) secreted by skeletal muscle mediate communications between muscle and liver, adipose tissue, brain, and other organs. Myokines affect muscle mass and myofiber switching, and have profound effects on glucose and lipid metabolism and inflammation, thus contributing to energy homeostasis and the pathogenesis of obesity, diabetes, and other diseases. In this review, we summarize recent findings on the biology of myokines and provide an assessment of their potential as therapeutic targets.
ISSN:2093-596X
2093-5978
DOI:10.3803/EnM.2015.30.3.235