Preparation and characterization of spray-dried gelatin microspheres encapsulating ganciclovir

• Published in: Macromolecular research 2014, 22(2), , pp.124-130
• Main Authors: Tran, Tuan Hiep, Ramasamy, Thiruganesh, Poudel, Bijay Kumar, Marasini, Nirmal, Moon, Bo Kyung, Cho, Hyuk Jun, Choi, Han-Gon, Yong, Chul Soon, Kim, Jong Oh
• Format: Article
• Language: English
• Subjects: Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Nanochemistry; Nanotechnology; Physical Chemistry; Polymer Sciences; Soft and Granular Matter; 고분자공학
• ISSN: 1598-5032; 2092-7673
• DOI: 10.1007/s13233-014-2018-9

The aim of this study was to prepare ganciclovir (GCV)-loaded cross-linked gelatin microspheres by spray-drying method. The microspheres were characterized in terms of particle size, surface morphology, loading efficiency, thermal behavior, physical characteristics, swelling properties, and the release profile in vitro . The major process and formulation parameters were optimized to obtain smaller particles with high loading capacity. The physical state examination confirmed the molecular-level dispersion of drug in the polymer. The loading efficiency determined by high-performance liquid chromatography (HPLC) was around 68%. The in vitro release experiments revealed that the GCV released from the gelatin microspheres was related to the extent of swelling, which was proportional to the drug-to-polymer ratio. These results suggest that cross-linked gelatin microspheres could be a suitable drug-delivery system for GCV.