Preparation of Furfuryl-fish gelatin (F-f.gel) cured using visible-light and its application as an anti-adhesion agent

Adhesions occurring on a variety tissues and operation sites are a serious side effect of surgery and may require additional surgery for removal. Therefore, Furfuryl-fish gelatin (F-f.gel) was synthesized by introducing a furan ring to fish gelatin for application as an anti-adhesion agent. F-f.gel...

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Bibliographic Details
Published in:Macromolecular research 2012, 20(8), , pp.842-846
Main Authors: Park, Shin-Hye, Seo, Si-Yoong, Lee, Hyung-Jae, Na, Ha-Na, Lee, Jea-Woo, Woo, Hee-Dong, Son, Tae-Il
Format: Article
Language:English
Subjects:
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Nanochemistry
Nanotechnology
Physical Chemistry
Polymer Sciences
Soft and Granular Matter
고분자공학
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Summary:Adhesions occurring on a variety tissues and operation sites are a serious side effect of surgery and may require additional surgery for removal. Therefore, Furfuryl-fish gelatin (F-f.gel) was synthesized by introducing a furan ring to fish gelatin for application as an anti-adhesion agent. F-f.gel was cured by visible-light irradiation, which changed the material from a solution to a film. The prepared F-f.gel was characterized by proton nuclear magnetic resonance spectroscopy ( 1 H NMR), substitution ratio, gel permeation chromatography (GPC), methyl thiazolyl tetrazolium (MTT) assay, and tests for measuring photo immobilization, water contact angle (WCA), and cell attachment. The results showed that F-f.gel was effective as an anti-adhesion agent.
ISSN:1598-5032
2092-7673
DOI:10.1007/s13233-012-0128-9