Beneficial Effects of Microwave-Induced Argon Plasma Treatment on Cellular Behaviors of Articular Chondrocytes Onto Nanofibrous Silk Fibroin Mesh

Silk fibroin scaffolds were examined as a biomaterial option for tissue-engineered cartilage-like tissue. In tissue engineering for cartilage repair using a scaffold, initial chondrocyte-material interactions are important for the following cell behaviors. In this study, the surface of nanofibrous s...

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Published in:Macromolecular research 2009, 17(9), , pp.703-708
Main Authors: Jin, Soo Chang, Baek, Hyun Sook, Woo, Yeon I, Lee, Mi Hee, Kim, Jung-Sung, Park, Jong-Chul, Park, Young Hwan, Rah, Dong Kyun, Chung, Kie-Hyung, Lee, Seung Jin, Han, In Ho
Format: Article
Language:English
Subjects:
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Nanochemistry
Nanotechnology
Physical Chemistry
Polymer Sciences
Soft and Granular Matter
고분자공학
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Summary:Silk fibroin scaffolds were examined as a biomaterial option for tissue-engineered cartilage-like tissue. In tissue engineering for cartilage repair using a scaffold, initial chondrocyte-material interactions are important for the following cell behaviors. In this study, the surface of nanofibrous silk fibroin (NSF) meshes was modified by a microwave-induced argon plasma treatment in order to improve the cytocompatibility of the meshes used as cartilaginous grafts. In addition, the effects of a plasma treatment on the cellular behavior of chondrocytes on NSF were examined. The plasma treatment resulted in an increase in the hydrophilicity of NSF meshes suggesting that the cytocompatibility of the mesh might be improved. Furthermore, the human articular chondrocytes showed higher viability on the surface-modified NSF meshes. These results suggest that the surface modification of NSF meshes by plasma can enhance the cellular behavior of chondrocytes and may be used in tissue engineering.
ISSN:1598-5032
2092-7673
DOI:10.1007/BF03218931