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Synthesis of 4-(2-Amino)ethoxy-3′,4′-dihydroxychalcones and Their Antioxidant and Cytotoxic Effects on Human Tumor Cells
Aminoethyl‐substituted chalcones 3 exhibiting potent 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical and superoxide anion radical scavenging activities and lipid peroxidation inhibitory activities along with cytotoxicities on four human tumor cells tested. Recently, many reports revealed that there are...
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Published in: | Bulletin of the Korean Chemical Society 2015, 36(5), , pp.1335-1339 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Aminoethyl‐substituted chalcones 3 exhibiting potent 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical and superoxide anion radical scavenging activities and lipid peroxidation inhibitory activities along with cytotoxicities on four human tumor cells tested.
Recently, many reports revealed that there are close correlations between antioxidant and anticancer activities of compounds. In this study, we designed 4‐hydroxy‐3′,4′‐dihydroxychalcone (2) as a ring‐opened analog of luteolin, which has been known to possess both antioxidant and anticancer activities, and then introduced aminoethyl moieties to this chalcone structure to increase water solubility by transforming into HCl salts. Synthesized aminoalkyl‐substituted chalcones 3a–3d showed potent antioxidant activities in three different assay systems and anticancer activities against four tumor cell lines tested. |
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ISSN: | 1229-5949 0253-2964 1229-5949 |
DOI: | 10.1002/bkcs.10253 |