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Synthesis of 4-(2-Amino)ethoxy-3′,4′-dihydroxychalcones and Their Antioxidant and Cytotoxic Effects on Human Tumor Cells

Aminoethyl‐substituted chalcones 3 exhibiting potent 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical and superoxide anion radical scavenging activities and lipid peroxidation inhibitory activities along with cytotoxicities on four human tumor cells tested. Recently, many reports revealed that there are...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2015, 36(5), , pp.1335-1339
Main Authors: Kim, Hyoung Ja, Kim, Seung Hwan, Lee, Young Hun, Kim, Dong Woon, Mo, Kilwoong, Kim, Hye Jin, Park, Sang Hoon, Jin, Changbae, Kim, Nam-Jung, Lee, Yong Sup
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Language:English
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Summary:Aminoethyl‐substituted chalcones 3 exhibiting potent 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical and superoxide anion radical scavenging activities and lipid peroxidation inhibitory activities along with cytotoxicities on four human tumor cells tested. Recently, many reports revealed that there are close correlations between antioxidant and anticancer activities of compounds. In this study, we designed 4‐hydroxy‐3′,4′‐dihydroxychalcone (2) as a ring‐opened analog of luteolin, which has been known to possess both antioxidant and anticancer activities, and then introduced aminoethyl moieties to this chalcone structure to increase water solubility by transforming into HCl salts. Synthesized aminoalkyl‐substituted chalcones 3a–3d showed potent antioxidant activities in three different assay systems and anticancer activities against four tumor cell lines tested.
ISSN:1229-5949
0253-2964
1229-5949
DOI:10.1002/bkcs.10253