Quercetin 7-O-Glutamate Potentiates Staphylococcus aureus to Fluoroquinolone Antibiotics

The quercetin conjugate Q‐7‐O‐Glu (5) showed inhibition of NorA efflux pump and thereby potentiation of antibacterial activity of various antibiotics against S. aureus. In particular, upon combination with 5, the fluoroquinolone antibiotics (ciprofloxacin) showed 4‐times enhanced antibacterial activ...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2016, 37(9), , pp.1515-1517
Main Authors: Park, Kwang-Su, Choo, Hyunah, Kim, Mi Kyoung, Chong, Youhoon
Format: Article
Language:English
Subjects:
Efflux pump inhibitor
Fluoroquinolone
Quercetin conjugate
Staphylococcus aureus
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Summary:The quercetin conjugate Q‐7‐O‐Glu (5) showed inhibition of NorA efflux pump and thereby potentiation of antibacterial activity of various antibiotics against S. aureus. In particular, upon combination with 5, the fluoroquinolone antibiotics (ciprofloxacin) showed 4‐times enhanced antibacterial activity against S. aureus.
ISSN:1229-5949
0253-2964
1229-5949
DOI:10.1002/bkcs.10901