Synthesis of Imidazo[1,2-a]pyridines and Pyrido[1,2-a]pyrimidines in Water and their SNAr Cyclizations

Synthesis of tetrahydroimidazo[1,2-a]pyridines and tetrahydropyrido[1,2-a] pyrimidines by a one-pot and three component reaction of α-oxoketenedithioacetals, diamines and DMAD in water has been described. Different routes for accessing the desired compounds were examined and a few specially designed...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2014, 35(4), , pp.994-1000
Main Authors: Langpoklakpam Gellina Chanu, Thokchom Prasanta Singh, Yong Ju Jang, 윤용진, Okram Mukherjee Singh, 이상경
Format: Article
Language:English
Subjects:
화학
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Summary:Synthesis of tetrahydroimidazo[1,2-a]pyridines and tetrahydropyrido[1,2-a] pyrimidines by a one-pot and three component reaction of α-oxoketenedithioacetals, diamines and DMAD in water has been described. Different routes for accessing the desired compounds were examined and a few specially designed-substrates have been utilized further to afford the new imidazo and pyrido fused [1,8] naphthyridine tetracyclic compound by SNAr intramolecular cyclization. KCI Citation Count: 10
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2014.35.4.994