Microwave Synthesis of Chiral N-Benzyl-2-methyl-2H-benzo[b][1,4]oxazin/thiazin-3(4H)-ones via Smiles Rearrangement and their Biological Evaluation

Optically active N-benzyl-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and N-benzyl-2-methyl-2H-benzo [b][1,4]thiazin-3(4H)-ones with potential synthetic and pharmacological interest were prepared via Smiles rearrangement in conventional as well as microwave irradiation conditions in one-pot from inex...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2013, 34(2), , pp.585-589
Main Authors: Meng, Li-Juan, Zuo, Hua, Vijaykumar, B.V.D., Dupati, Gautam, Choi, Kyung-Min, Jang, Kiwan, Yoon, Yong-Jin, Shin, Dong-Soo
Format: Article
Language:English
Subjects:
화학
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Summary:Optically active N-benzyl-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and N-benzyl-2-methyl-2H-benzo [b][1,4]thiazin-3(4H)-ones with potential synthetic and pharmacological interest were prepared via Smiles rearrangement in conventional as well as microwave irradiation conditions in one-pot from inexpensive (S)-2- chloropropionic acid. Most of the compounds displayed good inhibition against Gram positive bacteria and fungi in the antibiotic test. KCI Citation Count: 7
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2013.34.2.585