Synthesis of Biologically Active Chalcones and their Anti-inflammatory Effects

Chalcones have been reported to have various biological activities including antitumor, antiparasitic, antileishmanial, antioxidative, superoxide scavenging, antibacterial, and PTP1B activity. Due to the limited natural resources, we had to prepare sizable quantities of biologically active chalcones...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2012, 33(3), , pp.953-957
Main Authors: Jeon, Jae-Ho, Kim, Si-Jun, Kim, Cheol-Gi, Kim, Jin-Kyung, Jun, Jong-Gab
Format: Article
Language:English
Subjects:
화학
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Summary:Chalcones have been reported to have various biological activities including antitumor, antiparasitic, antileishmanial, antioxidative, superoxide scavenging, antibacterial, and PTP1B activity. Due to the limited natural resources, we had to prepare sizable quantities of biologically active chalcones for bio-tests. Therefore, Claisen-Schmidt condensation between substituted acetophenones and corresponding aldehydes enabled us to prepare chalcones for inflammatory studies. Chalcones thus prepared showed significant suppression of nitric oxide (NO) production at 10 μM. KCI Citation Count: 9
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2012.33.3.953