Photodynamic and Antioxidant Activities of Divalent Transition Metal Complexes of Methyl Pheophorbide-a

A comparative study of the photodynamic and antioxidant activities of methyl pheophorbide-a (MPa, 1) and its transition metal(II) complexes (2-5) is described. Four transition metal complexes (palladium(II): 2, zinc(II):3, cobalt(II): 4 and copper(II): 5) of MPa were prepared by reaction between the...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2011, 32(8), , pp.2981-2987
Main Authors: Yoon, Il, Park, Ho-Sung, Cui, Bing Cun, Li, Jia Zhu, Kim, Jung-Hwa, Lkhagvadulam, Byambajav, Shim, Young-Key
Format: Article
Language:English
Subjects:
화학
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Summary:A comparative study of the photodynamic and antioxidant activities of methyl pheophorbide-a (MPa, 1) and its transition metal(II) complexes (2-5) is described. Four transition metal complexes (palladium(II): 2, zinc(II):3, cobalt(II): 4 and copper(II): 5) of MPa were prepared by reaction between the corresponding transition metal and 1, respectively, and were characterized by 1H-NMR and UV-vis spectroscopic and mass spectrometric analyses. In vitro results show a photodynamic therapy (PDT) efficacy with A549 cells might be attributed to a heavy atom effect of the transition metal complexes of MPa. Among them, 4 and 5 showed higher photodynamic activity than that of 1 at the concentration of 5 μM at 24 h incubation after photoirradiation. The images of morphological change for 2-5 show evidence for the PDT effect with A549 cells. And the all transition metal complexes of MPa showed higher antioxidant activity than that of MPa, in which 4 showed the highest antioxidant activity. KCI Citation Count: 15
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2011.32.8.2981