Synthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers

The synthesis and biological evaluation of 1-heteroarylmethyl 1,4-diazepane derivatives as potential T-type calcium channel blockers is described. In this study, we have identified the compound 21i exhibiting the most potent T-type calcium channel blocking activity with IC_50 value of 0.20 μM, which...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2011, 32(8), , pp.3063-3073
Main Authors: Ullapu, Punna Reddy, Ku, Su-Jin, Choi, Yeon-Hee, Park, Ji-Yeon, Han, So-Yeop, Baek, Du-Jong, Lee, Jae-Kyun, Pae, Ae-Nim, Min, Sun-Joon, Cho, Yong-Seo
Format: Article
Language:English
Subjects:
화학
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Summary:The synthesis and biological evaluation of 1-heteroarylmethyl 1,4-diazepane derivatives as potential T-type calcium channel blockers is described. In this study, we have identified the compound 21i exhibiting the most potent T-type calcium channel blocking activity with IC_50 value of 0.20 μM, which is superior to that of mibefradil. KCI Citation Count: 4
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2011.32.8.3063