Chemical Constituents from Acer mandshuricum and Their Effects on the Function of Osteoblastic MC3T3-E1 Cells

A new compound, 4-methoxyl 5-hydroxymethyl benzoic 3-O-β-D-glucopyranoside (1), has been isolated from the leaves and stems of Acer mandshuricum, along with nine known compounds (2-10). Their structures were determined by a variety of spectroscopic analyses. The effect of compounds 1-10 on the funct...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2010, 31(4), , pp.929-933
Main Authors: Ding, Yan, Liang, Chun, Nguyen, Huu Tung, Choi, Eun-Mi, Kim, Jeong-Ah, Kim, Young-Ho
Format: Article
Language:English
Subjects:
화학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new compound, 4-methoxyl 5-hydroxymethyl benzoic 3-O-β-D-glucopyranoside (1), has been isolated from the leaves and stems of Acer mandshuricum, along with nine known compounds (2-10). Their structures were determined by a variety of spectroscopic analyses. The effect of compounds 1-10 on the function of osteoblastic MC3T3-E1 cells was examined by determining alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization. Compound 1significantly increased the function of osteoblastic MC3T3-E1 cells; 5.0 μM of 1 increased ALP activity, collagen synthesis,and mineralization of MC3T3-E1 cells to 114.7, 119.5, and 108.2% (P < 0.05) of the basal value, respectively. In addition, compounds 2-10 also potently increased the function of osteoblastic MC3T3-E1 cells. KCI Citation Count: 7
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2010.31.04.929