SAR Study of β-Aminoacyl-Containing Cyclic Hydrazide Derivatives as DPP-IV Inhibitors

continuation of our efforts to further derivatize dipeptidyl peptidase IV (DPP-IV) inhibitors, a series of β- aminoacyl-containing 5-, 6- and 7- membered cyclic hydrazide derivatives was synthesized. All the compounds were evaluated for their ability to inhibit DPP-IV, and an optimum structural unit...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2008, 29(11), , pp.2129-2134
Main Authors: Jin Hee Ahn, Mi Ae Jun, Mi Sik Shin, Seung Kyu Kang, Ki Young Kim, Sang Dal Rhee, Hyae Gyeong Cheon, Woul Seong Park, Duck Hyung Lee, Sung Soo Kim
Format: Article
Language:English
Subjects:
화학
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Summary:continuation of our efforts to further derivatize dipeptidyl peptidase IV (DPP-IV) inhibitors, a series of β- aminoacyl-containing 5-, 6- and 7- membered cyclic hydrazide derivatives was synthesized. All the compounds were evaluated for their ability to inhibit DPP-IV, and an optimum structural unit on basic skeleton is identified to show good in vitro activity. KCI Citation Count: 2
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2008.29.11.2129