Characterizations of Novel Poly(aspartic acid) Derivatives Conjugated with γ-Amino Butyric Acid (GABA) as the Bioactive Molecule

Novel poly(aspartic acid) derivatives conjugated with γ-amino butyric acid, GABA, moieties, and their amphiphilic analogs were synthesized and characterized. The chemical structures of these polymers were confirmed by FT-IR and 1H NMR spectroscopy. Their physicochemical properties in aqueous media w...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2009, 30(12), , pp.3025-3030
Main Authors: Kim, Seung-Il, Son, Chang-Mo, Jeon, Young-Sil, Kim, Ji-Heung
Format: Article
Language:English
Subjects:
화학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Novel poly(aspartic acid) derivatives conjugated with γ-amino butyric acid, GABA, moieties, and their amphiphilic analogs were synthesized and characterized. The chemical structures of these polymers were confirmed by FT-IR and 1H NMR spectroscopy. Their physicochemical properties in aqueous media were characterized by electrophonetic light scattering spectrophotometry (ELS), acid-base titration, and UV-spectroscopy. In addition, the in vitro cell activity of the GABA-conjugated polymer was examined. These results indicated that GABA-conjugated poly(aspartic acid) derivatives showed cell-growth activity and nanoparticle formation of a suitable size within aqueous media. These polymers have potential application in the cosmetic and pharmaceutical fields. KCI Citation Count: 15
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2009.30.12.3025