Amyloglucosidase Catalyzed Syntheses of Bakuchiol Glycosides in Supercritical Carbon Dioxide

Enzymatic syntheses of water soluble Bakuchiol glycosides were carried out in di-isopropyl ether organic media using amyloglucosidase from Rhizopus mold. The reactions were carried out under conventional reflux conditions and in supercritical CO2 atmospheric conditions. Out of the eleven carbohydrat...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2009, 30(8), , pp.1760-1766
Main Authors: Balaraman Manohar, Soundar Divakar, Kadimi Udaya Sankar
Format: Article
Language:English
Subjects:
화학
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Summary:Enzymatic syntheses of water soluble Bakuchiol glycosides were carried out in di-isopropyl ether organic media using amyloglucosidase from Rhizopus mold. The reactions were carried out under conventional reflux conditions and in supercritical CO2 atmospheric conditions. Out of the eleven carbohydrate molecules employed for the reaction, D-glucose, D-ribose and D-arabinose gave glycosides in yields of 9.0% to 51.4% under conventional reflux conditions. Under supercritical CO2 atmosphere (100 bar pressure at 50 oC), bakuchiol formed glycosides with Dglucose, D-galactose, D-mannose, D-fructose, D-ribose, D-arabinose, D-sorbitol and D-mannitol in yields ranging from 9% to 46.6%. Out of the bakuchiol glycosides prepared, 6-O-(6-D-fructofruranosyl)bakuchiol showed the best antioxidant (1.4 mM) and ACE inhibitory activities (0.64 mM). KCI Citation Count: 1
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2009.30.8.1760