Radioactivity Reduction of 2-Deoxy-2-[18F] Fluoro-D-Glucose by Milk and Ursodeoxycholic Acid in Preclinical Study

• Published in: Nuclear medicine and molecular imaging 2020, 54(2), , pp.105-113
• Main Authors: Jeong, Hwan-Jeong, Bagalkot, Tarique Rajasaheb, Kim, Hyeon Soo, Han, Yeon-Hee, Kim, Minjoo, Lim, Seok Tae, Sohn, Myung-Hee
• Format: Article
• Language: English
• Subjects: Brain; Cardiology; Diagnostic software; Diagnostic systems; Emission analysis; Fluorine isotopes; Glucose; Image acquisition; Imaging; Intestine; Large intestine; Liver; Measurement methods; Medicine; Medicine & Public Health; Milk; Nuclear Medicine; Oncology; Organs; Original; Original Article; Orthopedics; Positron emission; Radiation effects; Radioactivity; Radiology; Reduction; Small intestine; Tomography; 방사선과학
• ISSN: 1869-3474; 1869-3482
• DOI: 10.1007/s13139-020-00634-x

Purpose 2-Deoxy-2-[ 18 F] fluoro-d-glucose positron emission tomography ( 18 F-FDG-PET) is a less-invasive and widely used diagnostic tool for detection of malignant tumors. However, prolonged retention of 18 F-FDG in the body increases radiation exposure. This study evaluated the effect of oral administration of milk and ursodeoxycholic acid (UDCA) in terms of reducing radiation exposure by 18 F-FDG. Methods 18 F-FDG radioactivity was measured using a digital γ counter in the whole body and in various organs of rats after oral administration of milk and milk plus UDCA (milk + UDCA). Western blotting was performed to measure the expression levels of G6Pase, HK 2, CREB, FoxO1, and PGC-1α in the brain, liver, small intestine, and large intestine to assess the mechanism underlying the reduction in radiation exposure from 18 F-FDG by oral administration of milk and UDCA. Results We found a significant reduction in 18 F-FDG radioactivity in the whole body and in the brain, liver, and small and large intestines. Expression of G6Pase was significantly increased in the above-mentioned organs in the milk and milk + UDCA groups. Expression of HK 2 was significantly decreased in the brain and small intestine in the milk and milk + UDCA groups. CREB, FoxO1, and PGC-1α expression levels in the brain, liver, and small intestine were increased in the milk and milk + UDCA groups. However, expression of PGC-1α in the large intestine in the milk and milk + UDCA groups was significantly decreased compared with that in the control group. Conclusion The present study demonstrated that administration of milk and UDCA increased G6Pase expression levels and 18 F-FDG release from the tissue. These results suggest milk and UDCA could be used to reduce radiation exposure from 18 F-FDG after image acquisition. The mechanisms underpinning this phenomenon should be explored in a human study.